Gene basic information
| LiverAtlas Gene ID |
HuLG001361 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
EGFR |
|
Synonyms |
ERBB|ERBB1|HER1|PIG61|mENA |
|
Gene name |
epidermal growth factor receptor |
|
Gene Type |
protein-coding |
|
Chromosome |
7 |
|
Genomics Location |
7p12 |
|
Known cancer genes |
Yes |
|
Protein products |
Epidermal growth factor receptor variant EX12 14del Epidermal growth factor receptor variant A Epidermal growth factor receptor Epidermal growth factor receptor Putative uncharacterized protein EGFR |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:3236
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000139 |
Golgi membrane |
|
GO:0000166 |
nucleotide binding |
|
GO:0000902 |
cell morphogenesis |
|
GO:0001503 |
ossification |
|
GO:0001892 |
embryonic placenta development |
|
GO:0001942 |
hair follicle development |
|
GO:0003690 |
double-stranded DNA binding |
|
GO:0004710 |
MAP/ERK kinase kinase activity |
|
GO:0004713 |
protein tyrosine kinase activity |
|
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
|
GO:0004716 |
receptor signaling protein tyrosine kinase activity |
|
GO:0004888 |
transmembrane receptor activity |
|
GO:0005006 |
epidermal growth factor receptor activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005768 |
endosome |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005789 |
endoplasmic reticulum membrane |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005886 |
plasma membrane |
|
GO:0006950 |
response to stress |
|
GO:0007165 |
signal transduction |
|
GO:0007166 |
cell surface receptor linked signaling pathway |
|
GO:0007173 |
epidermal growth factor receptor signaling pathway |
|
GO:0007202 |
activation of phospholipase C activity |
|
GO:0007411 |
axon guidance |
|
GO:0007435 |
salivary gland morphogenesis |
|
GO:0008283 |
cell proliferation |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0016020 |
membrane |
|
GO:0016021 |
integral to membrane |
|
GO:0016323 |
basolateral plasma membrane |
|
GO:0016337 |
cell-cell adhesion |
|
GO:0019903 |
protein phosphatase binding |
|
GO:0021795 |
cerebral cortex cell migration |
|
GO:0030122 |
AP-2 adaptor complex |
|
GO:0030139 |
endocytic vesicle |
|
GO:0030235 |
nitric-oxide synthase regulator activity |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0031659 |
positive regulation of cyclin-dependent protein kinase activity involved in G1/S |
|
GO:0031965 |
nuclear membrane |
|
GO:0035413 |
positive regulation of catenin import into nucleus |
|
GO:0042059 |
negative regulation of epidermal growth factor receptor signaling pathway |
|
GO:0042327 |
positive regulation of phosphorylation |
|
GO:0042802 |
identical protein binding |
|
GO:0043006 |
activation of phospholipase A2 activity by calcium-mediated signaling |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043406 |
positive regulation of MAP kinase activity |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0046777 |
protein autophosphorylation |
|
GO:0046982 |
protein heterodimerization activity |
|
GO:0048546 |
digestive tract morphogenesis |
|
GO:0050679 |
positive regulation of epithelial cell proliferation |
|
GO:0050730 |
regulation of peptidyl-tyrosine phosphorylation |
|
GO:0050999 |
regulation of nitric-oxide synthase activity |
|
GO:0051015 |
actin filament binding |
|
GO:0051205 |
protein insertion into membrane |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0060571 |
morphogenesis of an epithelial fold |
|
GO:0070141 |
response to UV-A |
|
GO:0070435 |
Shc-EGFR complex |
