HuLG001383

Entrez Gene ID

1991

Official Gene Symbol

ELANE

Synonyms

ELA2|GE|HLE|HNE|NE|PMNNE|SCN1

Gene name

elastase, neutrophil expressed

Gene Type

protein-coding

Chromosome

19

Genomics Location

19p13.3

Known cancer genes

Yes

Protein products

Neutrophil elastase

Neutrophil elastase

Related liver disease name

Liver fibrosis and liver cirrhosis

Nonalcoholic steatohepatitis

Database cross reference

HGNC:3309
MIM:130130
Ensembl:ENSG00000197561
HPRD:00554
RefSeq Genomic nucleotide accession:AC_000062
RefSeq Genomic nucleotide gi:89161197

GO annotation

GO:0001878

response to yeast

GO:0002438

acute inflammatory response to antigenic stimulus

GO:0004175

endopeptidase activity

GO:0004252

serine-type endopeptidase activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005737

cytoplasm

GO:0006508

proteolysis

GO:0006874

cellular calcium ion homeostasis

GO:0006909

phagocytosis

GO:0008201

heparin binding

GO:0008233

peptidase activity

GO:0009411

response to UV

GO:0009986

cell surface

GO:0019955

cytokine binding

GO:0030141

stored secretory granule

GO:0030163

protein catabolic process

GO:0032496

response to lipopolysaccharide

GO:0043406

positive regulation of MAP kinase activity

GO:0044130

negative regulation of growth of symbiont in host

GO:0045079

negative regulation of chemokine biosynthetic process

GO:0045415

negative regulation of interleukin-8 biosynthetic process

GO:0045416

positive regulation of interleukin-8 biosynthetic process

GO:0048661

positive regulation of smooth muscle cell proliferation

GO:0050728

negative regulation of inflammatory response

GO:0050778

positive regulation of immune response

GO:0050900

leukocyte migration

GO:0050922

negative regulation of chemotaxis

GO:0051635

bacterial cell surface binding

GO:0070947

neutrophil mediated killing of fungus