Gene basic information
| LiverAtlas Gene ID |
HuLG001451 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
ERCC2 |
|
Synonyms |
COFS2|EM9|MGC102762|MGC126218|MGC126219|TTD|XPD |
|
Gene name |
excision repair cross-complementing rodent repair deficiency, complementation group 2 |
|
Gene Type |
protein-coding |
|
Chromosome |
19 |
|
Genomics Location |
19q13.3 |
|
Known cancer genes |
Yes |
|
Protein products |
TFIIH basal transcription factor complex helicase XPD subunit |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:3434
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000075 |
cell cycle checkpoint |
|
GO:0000166 |
nucleotide binding |
|
GO:0000718 |
nucleotide-excision repair, DNA damage removal |
|
GO:0001701 |
in utero embryonic development |
|
GO:0004003 |
ATP-dependent DNA helicase activity |
|
GO:0004386 |
helicase activity |
|
GO:0004672 |
protein kinase activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005675 |
holo TFIIH complex |
|
GO:0005737 |
cytoplasm |
|
GO:0005819 |
spindle |
|
GO:0005856 |
cytoskeleton |
|
GO:0006139 |
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
|
GO:0006281 |
DNA repair |
|
GO:0006283 |
transcription-coupled nucleotide-excision repair |
|
GO:0006289 |
nucleotide-excision repair |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006360 |
transcription from RNA polymerase I promoter |
|
GO:0006361 |
transcription initiation from RNA polymerase I promoter |
|
GO:0006362 |
transcription elongation from RNA polymerase I promoter |
|
GO:0006363 |
termination of RNA polymerase I transcription |
|
GO:0006366 |
transcription from RNA polymerase II promoter |
|
GO:0006367 |
transcription initiation from RNA polymerase II promoter |
|
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
|
GO:0006370 |
mRNA capping |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007059 |
chromosome segregation |
|
GO:0007568 |
aging |
|
GO:0008022 |
protein C-terminus binding |
|
GO:0008094 |
DNA-dependent ATPase activity |
|
GO:0008283 |
cell proliferation |
|
GO:0008353 |
RNA polymerase II carboxy-terminal domain kinase activity |
|
GO:0009650 |
UV protection |
|
GO:0009791 |
post-embryonic development |
|
GO:0010467 |
gene expression |
|
GO:0016032 |
viral reproduction |
|
GO:0016818 |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
|
GO:0019907 |
cyclin-dependent protein kinase activating kinase holoenzyme complex |
|
GO:0021510 |
spinal cord development |
|
GO:0030198 |
extracellular matrix organization |
|
GO:0030282 |
bone mineralization |
|
GO:0032289 |
central nervous system myelin formation |
|
GO:0033683 |
nucleotide-excision repair, DNA incision |
|
GO:0035264 |
multicellular organism growth |
|
GO:0035315 |
hair cell differentiation |
|
GO:0040016 |
embryonic cleavage |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043139 |
5'-3' DNA helicase activity |
|
GO:0043249 |
erythrocyte maturation |
|
GO:0043388 |
positive regulation of DNA binding |
|
GO:0043588 |
skin development |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046872 |
metal ion binding |
|
GO:0047485 |
protein N-terminus binding |
|
GO:0048820 |
hair follicle maturation |
|
GO:0050434 |
positive regulation of viral transcription |
|
GO:0051536 |
iron-sulfur cluster binding |
|
GO:0060218 |
hemopoietic stem cell differentiation |
|
GO:0071817 |
MMXD complex |
