HuLG001498

Entrez Gene ID

2147

Official Gene Symbol

F2

Synonyms

PT

Gene name

coagulation factor II (thrombin)

Gene Type

protein-coding

Chromosome

11

Genomics Location

11p11

Known cancer genes

Yes

Protein products

Prothrombin

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Autoimmune hepatitis

Alcoholic hepatitis

Alcoholic liver cirrhosis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:3535
MIM:176930
Ensembl:ENSG00000180210
HPRD:01488
RefSeq Genomic nucleotide accession:AC_000054
RefSeq Genomic nucleotide gi:89161188

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0001934

positive regulation of protein phosphorylation

GO:0004252

serine-type endopeptidase activity

GO:0005102

receptor binding

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005625

soluble fraction

GO:0005788

endoplasmic reticulum lumen

GO:0005796

Golgi lumen

GO:0005886

plasma membrane

GO:0006508

proteolysis

GO:0006915

apoptosis

GO:0006919

activation of caspase activity

GO:0006953

acute-phase response

GO:0007166

cell surface receptor linked signaling pathway

GO:0007260

tyrosine phosphorylation of STAT protein

GO:0007262

STAT protein import into nucleus

GO:0007275

multicellular organismal development

GO:0007596

blood coagulation

GO:0007597

blood coagulation, intrinsic pathway

GO:0008083

growth factor activity

GO:0008233

peptidase activity

GO:0008284

positive regulation of cell proliferation

GO:0008360

regulation of cell shape

GO:0009611

response to wounding

GO:0010544

negative regulation of platelet activation

GO:0014068

positive regulation of phosphatidylinositol 3-kinase cascade

GO:0017187

peptidyl-glutamic acid carboxylation

GO:0030168

platelet activation

GO:0030193

regulation of blood coagulation

GO:0030194

positive regulation of blood coagulation

GO:0030307

positive regulation of cell growth

GO:0032967

positive regulation of collagen biosynthetic process

GO:0042730

fibrinolysis

GO:0043687

post-translational protein modification

GO:0044267

cellular protein metabolic process

GO:0045861

negative regulation of proteolysis

GO:0048712

negative regulation of astrocyte differentiation

GO:0050900

leukocyte migration

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO:0051480

cytosolic calcium ion homeostasis

GO:0051918

negative regulation of fibrinolysis

GO:0070053

thrombospondin receptor activity

GO:2000379

positive regulation of reactive oxygen species metabolic process