HuLG001499

Entrez Gene ID

2149

Official Gene Symbol

F2R

Synonyms

CF2R|HTR|PARN1|PAR1|TR

Gene name

coagulation factor II (thrombin) receptor

Gene Type

protein-coding

Chromosome

5

Genomics Location

5q13

Known cancer genes

Yes

Protein products

Proteinase-activated receptor 1

Cell proliferation-inducing protein 18

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Database cross reference

HGNC:3537
MIM:187930
Ensembl:ENSG00000181104
HPRD:01763
RefSeq Genomic nucleotide accession:AC_000048
RefSeq Genomic nucleotide gi:89161208

GO annotation

GO:0000186

activation of MAPKK activity

GO:0002248

connective tissue replacement involved in inflammatory response wound healing

GO:0004872

receptor activity

GO:0004930

G-protein coupled receptor activity

GO:0005102

receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005794

Golgi apparatus

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0005901

caveola

GO:0006919

activation of caspase activity

GO:0006954

inflammatory response

GO:0007186

G-protein coupled receptor protein signaling pathway

GO:0007205

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

GO:0007260

tyrosine phosphorylation of STAT protein

GO:0007262

STAT protein import into nucleus

GO:0007529

establishment of synaptic specificity at neuromuscular junction

GO:0007596

blood coagulation

GO:0008284

positive regulation of cell proliferation

GO:0008285

negative regulation of cell proliferation

GO:0009611

response to wounding

GO:0009653

anatomical structure morphogenesis

GO:0014068

positive regulation of phosphatidylinositol 3-kinase cascade

GO:0015057

thrombin receptor activity

GO:0016265

death

GO:0030168

platelet activation

GO:0030193

regulation of blood coagulation

GO:0030194

positive regulation of blood coagulation

GO:0030335

positive regulation of cell migration

GO:0031094

platelet dense tubular network

GO:0031594

neuromuscular junction

GO:0032496

response to lipopolysaccharide

GO:0032651

regulation of interleukin-1 beta production

GO:0032967

positive regulation of collagen biosynthetic process

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

GO:0043280

positive regulation of caspase activity

GO:0043410

positive regulation of MAPKKK cascade

GO:0043524

negative regulation of neuron apoptosis

GO:0045211

postsynaptic membrane

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0045907

positive regulation of vasoconstriction

GO:0045987

positive regulation of smooth muscle contraction

GO:0046427

positive regulation of JAK-STAT cascade

GO:0048873

homeostasis of number of cells within a tissue

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

GO:0051482

elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger

GO:0051928

positive regulation of calcium ion transport

GO:0051930

regulation of sensory perception of pain

GO:0060155

platelet dense granule organization

GO:0070493

thrombin receptor signaling pathway