HuLG001565

Entrez Gene ID

2237

Official Gene Symbol

FEN1

Synonyms

FENN1|MF1|RAD2

Gene name

flap structure-specific endonuclease 1

Gene Type

protein-coding

Chromosome

11

Genomics Location

11q12

Known cancer genes

Yes

Protein products

Flap endonuclease 1

FEN1 protein

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:3650
MIM:600393
Ensembl:ENSG00000168496
HPRD:02670
RefSeq Genomic nucleotide accession:AC_000054
RefSeq Genomic nucleotide gi:89161188

HCC significant genes

Yes/No

Yes

Evidence

EHCO OncoDB

Quality score

GO annotation

GO:0000084

S phase of mitotic cell cycle

GO:0000278

mitotic cell cycle

GO:0000722

telomere maintenance via recombination

GO:0000723

telomere maintenance

GO:0003677

DNA binding

GO:0003684

damaged DNA binding

GO:0003690

double-stranded DNA binding

GO:0004519

endonuclease activity

GO:0004523

ribonuclease H activity

GO:0004527

exonuclease activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005730

nucleolus

GO:0005739

mitochondrion

GO:0006260

DNA replication

GO:0006271

DNA strand elongation involved in DNA replication

GO:0006281

DNA repair

GO:0006284

base-excision repair

GO:0006302

double-strand break repair

GO:0008309

double-stranded DNA specific exodeoxyribonuclease activity

GO:0008409

5'-3' exonuclease activity

GO:0009650

UV protection

GO:0017108

5'-flap endonuclease activity

GO:0032201

telomere maintenance via semi-conservative replication

GO:0043137

DNA replication, removal of RNA primer

GO:0046872

metal ion binding

GO:0048015

phosphatidylinositol-mediated signaling