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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG001632

Entrez Gene ID

2321

Official Gene Symbol

FLT1

Synonyms

FLT|VEGFR1

Gene name

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Gene Type

protein-coding

Chromosome

13

Genomics Location

13q12

Known cancer genes

Yes

Protein products

IdVEGFR-1

Tyrosine-protein kinase receptor

PsVEGFR1p

Soluble VEGFR1 variant 21

Soluble VEGFR1 variant 2

Vascular endothelial growth factor receptor 1

Related liver disease name

Hepatocellular carcinoma

Database cross reference

HGNC:3763
MIM:165070
Ensembl:ENSG00000102755
HPRD:01297
RefSeq Genomic nucleotide accession:AC_000056
RefSeq Genomic nucleotide gi:89161191

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000166

nucleotide binding

GO:0000186

activation of MAPKK activity

GO:0001569

patterning of blood vessels

GO:0001666

response to hypoxia

GO:0002040

sprouting angiogenesis

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO:0004872

receptor activity

GO:0005021

vascular endothelial growth factor receptor activity

GO:0005524

ATP binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005634

nucleus

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0005794

Golgi apparatus

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006940

regulation of smooth muscle contraction

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

GO:0007275

multicellular organismal development

GO:0007565

female pregnancy

GO:0008284

positive regulation of cell proliferation

GO:0019838

growth factor binding

GO:0030154

cell differentiation

GO:0030335

positive regulation of cell migration

GO:0030522

intracellular receptor mediated signaling pathway

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

GO:0042802

identical protein binding

GO:0048010

vascular endothelial growth factor receptor signaling pathway

GO:0048661

positive regulation of smooth muscle cell proliferation