HuLG002041

Entrez Gene ID

3002

Official Gene Symbol

GZMB

Synonyms

CCPI|CGLN1|CGL1|CSPNB|CSPB|CTLA1|CTSGL1|HLP|SECT

Gene name

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Gene Type

protein-coding

Chromosome

14

Genomics Location

14q11.2

Protein products

Uncharacterized protein

Granzyme B

Endogenous granzyme B

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatitis B

Chronic hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:4709
MIM:123910
Ensembl:ENSG00000100453
HPRD:00476
RefSeq Genomic nucleotide accession:AC_000057
RefSeq Genomic nucleotide gi:89161192

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0001772

immunological synapse

GO:0004252

serine-type endopeptidase activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006508

proteolysis

GO:0006915

apoptosis

GO:0006922

cleavage of lamin

GO:0008233

peptidase activity

GO:0008236

serine-type peptidase activity

GO:0008629

induction of apoptosis by intracellular signals

GO:0008633

activation of pro-apoptotic gene products

GO:0019835

cytolysis

GO:0043231

intracellular membrane-bounded organelle