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Gene basic information

LiverAtlas Gene ID	HuLG002105
Entrez Gene ID	3084
Official Gene Symbol	NRG1
Synonyms	ARIA\|GGF\|GGF2\|HGL\|HRG\|HRG1\|HRGA\|MST131\|NDF\|SMDF
Gene name	neuregulin 1
Gene Type	protein-coding
Chromosome	8
Genomics Location	8p12
Known cancer genes	Yes
Protein products	Neuregulin 1 type IV fetal B beta 1a Neuregulin 1 type IV fetal C beta 1a Heregulin-beta 3 protein isoform Heregulin-gamma protein isoform 1 Heregulin-gamma protein isoform 2 Neuregulin 1 isoform ndf43-beta2 Neuregulin 1 isoform HRG-gamma Neuregulin 1 isoform HRG-alpha cDNA FLJ52471, highly similar to Homo sapiens neuregulin 1 (NRG1), transcript variant ndf43, mRNA cDNA FLJ61326, highly similar to Pro-neuregulin-1, membrane-bound isoform Neuregulin 1 Uncharacterized protein Pro-neuregulin-1, membrane-bound isoform NRG1 protein Neuregulin 1 Neuregulin 1 isoform HRG-alpha Neuregulin 1 isoform HRG-beta2 Neuregulin 1 isoform HRG-beta1 Neuregulin 1 isoform HRG-gamma Neuregulin 1 isoform 4 Neuregulin 1
Related liver disease name	Hepatitis Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E Hepatocellular carcinoma
Database cross reference	HGNC:7997 MIM:142445 Ensembl:ENSG00000157168 HPRD:00802 RefSeq Genomic nucleotide accession:AC_000051 RefSeq Genomic nucleotide gi:89161214

Liver relevance

HCC significant genes	Yes/No	Yes
	Evidence	EHCO HCC.net OncoDB
	Quality score

Ontology annotation

GO ID	GO annotation
GO:0003712	transcription cofactor activity
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0006916	anti-apoptosis
GO:0007154	cell communication
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007219	Notch signaling pathway
GO:0007399	nervous system development
GO:0008083	growth factor activity
GO:0008283	cell proliferation
GO:0009790	embryo development
GO:0010667	negative regulation of cardiac muscle cell apoptosis
GO:0014032	neural crest cell development
GO:0016020	membrane
GO:0016021	integral to membrane
GO:0016324	apical plasma membrane
GO:0030296	protein tyrosine kinase activator activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0030307	positive regulation of cell growth
GO:0030879	mammary gland development
GO:0030971	receptor tyrosine kinase binding
GO:0042060	wound healing
GO:0043125	ErbB-3 class receptor binding
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0043624	cellular protein complex disassembly
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-dependent
GO:0051048	negative regulation of secretion
GO:0051155	positive regulation of striated muscle cell differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0055012	ventricular cardiac muscle cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0061098	positive regulation of protein tyrosine kinase activity