Gene basic information
| LiverAtlas Gene ID |
HuLG002152 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
HMGCL |
|
Synonyms |
HL |
|
Gene name |
3-hydroxymethyl-3-methylglutaryl-CoA lyase |
|
Gene Type |
protein-coding |
|
Chromosome |
1 |
|
Genomics Location |
1p36.1-p35 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ53101, highly similar to Hydroxymethylglutaryl-CoA lyase, mitochondrial (EC 4.1.3.4) Hydroxymethylglutaryl-CoA lyase, mitochondrial 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (Hydroxymethylglutaricaciduria) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:5005
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000062 |
fatty-acyl-CoA binding |
|
GO:0001889 |
liver development |
|
GO:0004419 |
hydroxymethylglutaryl-CoA lyase activity |
|
GO:0005739 |
mitochondrion |
|
GO:0005743 |
mitochondrial inner membrane |
|
GO:0005759 |
mitochondrial matrix |
|
GO:0006637 |
acyl-CoA metabolic process |
|
GO:0007005 |
mitochondrion organization |
|
GO:0007584 |
response to nutrient |
|
GO:0009790 |
embryo development |
|
GO:0016829 |
lyase activity |
|
GO:0031406 |
carboxylic acid binding |
|
GO:0042594 |
response to starvation |
|
GO:0043441 |
acetoacetic acid biosynthetic process |
|
GO:0044255 |
cellular lipid metabolic process |
|
GO:0046872 |
metal ion binding |
|
GO:0046950 |
cellular ketone body metabolic process |
|
GO:0046951 |
ketone body biosynthetic process |
|
GO:0070542 |
response to fatty acid |
