Gene basic information
| LiverAtlas Gene ID |
HuLG002167 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
HNF4A |
|
Synonyms |
FLJ39654|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14 |
|
Gene name |
hepatocyte nuclear factor 4, alpha |
|
Gene Type |
protein-coding |
|
Chromosome |
20 |
|
Genomics Location |
20q13.12 |
|
Known cancer genes |
Yes |
|
Protein products |
Hepatocyte nuclear factor 4, alpha Hepatocyte nuclear factor 4 4 alpha variant 1 Hepatocyte nuclear factor 4 4 alpha variant 4 Hepatocyte nuclear factor 4 4 alpha variant 2 Hepatocyte nuclear factor 4-alpha Hepatocyte nuclear factor 4, alpha |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:5024
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000062 |
fatty-acyl-CoA binding |
|
GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
|
GO:0003677 |
DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0003705 |
sequence-specific enhancer binding RNA polymerase II transcription factor activity |
|
GO:0003707 |
steroid hormone receptor activity |
|
GO:0005102 |
receptor binding |
|
GO:0005504 |
fatty acid binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005667 |
transcription factor complex |
|
GO:0005737 |
cytoplasm |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
|
GO:0006591 |
ornithine metabolic process |
|
GO:0006637 |
acyl-CoA metabolic process |
|
GO:0006805 |
xenobiotic metabolic process |
|
GO:0007164 |
establishment of tissue polarity |
|
GO:0007548 |
sex differentiation |
|
GO:0007596 |
blood coagulation |
|
GO:0008270 |
zinc ion binding |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0010467 |
gene expression |
|
GO:0010470 |
regulation of gastrulation |
|
GO:0016290 |
palmitoyl-CoA hydrolase activity |
|
GO:0019216 |
regulation of lipid metabolic process |
|
GO:0030154 |
cell differentiation |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0031018 |
endocrine pancreas development |
|
GO:0032534 |
regulation of microvillus assembly |
|
GO:0033159 |
negative regulation of protein import into nucleus, translocation |
|
GO:0033613 |
activating transcription factor binding |
|
GO:0034339 |
regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor |
|
GO:0042493 |
response to drug |
|
GO:0042524 |
negative regulation of tyrosine phosphorylation of Stat5 protein |
|
GO:0042593 |
glucose homeostasis |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0045216 |
cell-cell junction organization |
|
GO:0045722 |
positive regulation of gluconeogenesis |
|
GO:0045723 |
positive regulation of fatty acid biosynthetic process |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045930 |
negative regulation of mitotic cell cycle |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046872 |
metal ion binding |
|
GO:0050732 |
negative regulation of peptidyl-tyrosine phosphorylation |
|
GO:0050796 |
regulation of insulin secretion |
|
GO:0051591 |
response to cAMP |
|
GO:0055088 |
lipid homeostasis |
|
GO:0055091 |
phospholipid homeostasis |
|
GO:0060395 |
SMAD protein signal transduction |
|
GO:0060398 |
regulation of growth hormone receptor signaling pathway |
|
GO:0070328 |
triglyceride homeostasis |
|
GO:0070491 |
repressing transcription factor binding |
|
GO:2000189 |
positive regulation of cholesterol homeostasis |
