HuLG002288

Entrez Gene ID

3357

Official Gene Symbol

HTR2B

Synonyms

5NHT(2B)|5NHT2B

Gene name

5-hydroxytryptamine (serotonin) receptor 2B

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q36.3-q37.1

Protein products

5-hydroxytryptamine receptor 2B

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatocellular carcinoma

Database cross reference

HGNC:5294
MIM:601122
Ensembl:ENSG00000135914
HPRD:03077
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

GO annotation

GO:0001755

neural crest cell migration

GO:0001819

positive regulation of cytokine production

GO:0001938

positive regulation of endothelial cell proliferation

GO:0001965

G-protein alpha-subunit binding

GO:0002031

G-protein coupled receptor internalization

GO:0003007

heart morphogenesis

GO:0003300

cardiac muscle hypertrophy

GO:0004435

phosphatidylinositol phospholipase C activity

GO:0004872

receptor activity

GO:0004930

G-protein coupled receptor activity

GO:0004993

serotonin receptor activity

GO:0005099

Ras GTPase activator activity

GO:0005262

calcium channel activity

GO:0005737

cytoplasm

GO:0005886

plasma membrane

GO:0006182

cGMP biosynthetic process

GO:0006661

phosphatidylinositol biosynthetic process

GO:0007186

G-protein coupled receptor protein signaling pathway

GO:0007205

activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway

GO:0007210

serotonin receptor signaling pathway

GO:0008144

drug binding

GO:0008284

positive regulation of cell proliferation

GO:0010507

negative regulation of autophagy

GO:0014033

neural crest cell differentiation

GO:0014065

phosphatidylinositol 3-kinase cascade

GO:0014827

intestine smooth muscle contraction

GO:0016021

integral to membrane

GO:0016310

phosphorylation

GO:0019722

calcium-mediated signaling

GO:0032320

positive regulation of Ras GTPase activity

GO:0042310

vasoconstriction

GO:0042493

response to drug

GO:0043066

negative regulation of apoptosis

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB cascade

GO:0043406

positive regulation of MAP kinase activity

GO:0048598

embryonic morphogenesis

GO:0050715

positive regulation of cytokine secretion

GO:0050795

regulation of behavior

GO:0051000

positive regulation of nitric-oxide synthase activity

GO:0051209

release of sequestered calcium ion into cytosol

GO:0051378

serotonin binding

GO:0051781

positive regulation of cell division

GO:0060548

negative regulation of cell death

GO:0070371

ERK1 and ERK2 cascade

GO:0070528

protein kinase C signaling cascade

GO:0070588

calcium ion transmembrane transport

GO:0071277

cellular response to calcium ion

GO:0071502

cellular response to temperature stimulus