Gene basic information
| LiverAtlas Gene ID |
HuLG002310 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
IDE |
|
Synonyms |
FLJ35968|INSULYSIN |
|
Gene name |
insulin-degrading enzyme |
|
Gene Type |
protein-coding |
|
Chromosome |
10 |
|
Genomics Location |
10q23-q25 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA, FLJ79306, highly similar to Insulin-degrading enzyme (EC 3.4.24.56) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:5381
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0001540 |
beta-amyloid binding |
|
GO:0004222 |
metalloendopeptidase activity |
|
GO:0004871 |
signal transducer activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005615 |
extracellular space |
|
GO:0005625 |
soluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005777 |
peroxisome |
|
GO:0005782 |
peroxisomal matrix |
|
GO:0005829 |
cytosol |
|
GO:0006508 |
proteolysis |
|
GO:0007165 |
signal transduction |
|
GO:0007548 |
sex differentiation |
|
GO:0008233 |
peptidase activity |
|
GO:0008270 |
zinc ion binding |
|
GO:0009986 |
cell surface |
|
GO:0010815 |
bradykinin catabolic process |
|
GO:0016887 |
ATPase activity |
|
GO:0031597 |
cytosolic proteasome complex |
|
GO:0031626 |
beta-endorphin binding |
|
GO:0042447 |
hormone catabolic process |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043559 |
insulin binding |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045861 |
negative regulation of proteolysis |
|
GO:0046872 |
metal ion binding |
|
GO:0050435 |
beta-amyloid metabolic process |
|
GO:0051289 |
protein homotetramerization |
|
GO:0051291 |
protein heterooligomerization |
|
GO:0051603 |
proteolysis involved in cellular protein catabolic process |
