HuLG002340

Entrez Gene ID

3458

Official Gene Symbol

IFNG

Synonyms

IFG|IFI

Gene name

interferon, gamma

Gene Type

protein-coding

Chromosome

12

Genomics Location

12q14

Known cancer genes

Yes

Protein products

Interferon gamma

Interferon gamma

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Liver fibrosis and liver cirrhosis caused by hepatitis C infection

Schistosomiasis

Database cross reference

HGNC:5438
MIM:147570
Ensembl:ENSG00000111537
HPRD:00957
RefSeq Genomic nucleotide accession:AC_000055
RefSeq Genomic nucleotide gi:89161189

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0000060

protein import into nucleus, translocation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001781

neutrophil apoptosis

GO:0002026

regulation of the force of heart contraction

GO:0002053

positive regulation of mesenchymal cell proliferation

GO:0003340

negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

GO:0005125

cytokine activity

GO:0005133

interferon-gamma receptor binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005622

intracellular

GO:0006925

inflammatory cell apoptosis

GO:0006928

cellular component movement

GO:0007050

cell cycle arrest

GO:0007166

cell surface receptor linked signaling pathway

GO:0009615

response to virus

GO:0019221

cytokine-mediated signaling pathway

GO:0019882

antigen processing and presentation

GO:0030593

neutrophil chemotaxis

GO:0030968

endoplasmic reticulum unfolded protein response

GO:0031642

negative regulation of myelination

GO:0032224

positive regulation of synaptic transmission, cholinergic

GO:0032700

negative regulation of interleukin-17 production

GO:0032735

positive regulation of interleukin-12 production

GO:0032747

positive regulation of interleukin-23 production

GO:0033141

positive regulation of peptidyl-serine phosphorylation of STAT protein

GO:0034393

positive regulation of smooth muscle cell apoptosis

GO:0040008

regulation of growth

GO:0042102

positive regulation of T cell proliferation

GO:0042493

response to drug

GO:0042511

positive regulation of tyrosine phosphorylation of Stat1 protein

GO:0042742

defense response to bacterium

GO:0042832

defense response to protozoan

GO:0044130

negative regulation of growth of symbiont in host

GO:0045080

positive regulation of chemokine biosynthetic process

GO:0045084

positive regulation of interleukin-12 biosynthetic process

GO:0045348

positive regulation of MHC class II biosynthetic process

GO:0045410

positive regulation of interleukin-6 biosynthetic process

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO:0045666

positive regulation of neuron differentiation

GO:0045672

positive regulation of osteoclast differentiation

GO:0045785

positive regulation of cell adhesion

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0048304

positive regulation of isotype switching to IgG isotypes

GO:0048662

negative regulation of smooth muscle cell proliferation

GO:0050718

positive regulation of interleukin-1 beta secretion

GO:0050776

regulation of immune response

GO:0050796

regulation of insulin secretion

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

GO:0051712

positive regulation of killing of cells of other organism

GO:0060333

interferon-gamma-mediated signaling pathway

GO:0060334

regulation of interferon-gamma-mediated signaling pathway

GO:0060550

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity

GO:0060552

positive regulation of fructose 1,6-bisphosphate metabolic process

GO:0060557

positive regulation of vitamin D biosynthetic process

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

GO:0072308

negative regulation of metanephric nephron tubule epithelial cell differentiation

GO:2000309

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production