Gene basic information
| LiverAtlas Gene ID |
HuLG002347 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
IGF1 |
|
Synonyms |
IGFNI|IGF1A|IGFI |
|
Gene name |
insulin-like growth factor 1 (somatomedin C) |
|
Gene Type |
protein-coding |
|
Chromosome |
12 |
|
Genomics Location |
12q23.2 |
|
Known cancer genes |
Yes |
|
Protein products |
Insulin-like growth factor 1 (Somatomedin C), isoform CRA c |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:5464
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001501 |
skeletal system development |
|
GO:0001932 |
regulation of protein phosphorylation |
|
GO:0001974 |
blood vessel remodeling |
|
GO:0002576 |
platelet degranulation |
|
GO:0005158 |
insulin receptor binding |
|
GO:0005159 |
insulin-like growth factor receptor binding |
|
GO:0005178 |
integrin binding |
|
GO:0005179 |
hormone activity |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0006260 |
DNA replication |
|
GO:0006916 |
anti-apoptosis |
|
GO:0006928 |
cellular component movement |
|
GO:0007165 |
signal transduction |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0007399 |
nervous system development |
|
GO:0007517 |
muscle organ development |
|
GO:0007596 |
blood coagulation |
|
GO:0008083 |
growth factor activity |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0009441 |
glycolate metabolic process |
|
GO:0010001 |
glial cell differentiation |
|
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase cascade |
|
GO:0014834 |
satellite cell maintenance involved in skeletal muscle regeneration |
|
GO:0014896 |
muscle hypertrophy |
|
GO:0014904 |
myotube cell development |
|
GO:0014911 |
positive regulation of smooth muscle cell migration |
|
GO:0016942 |
insulin-like growth factor binding protein complex |
|
GO:0021940 |
positive regulation of cerebellar granule cell precursor proliferation |
|
GO:0030104 |
water homeostasis |
|
GO:0030166 |
proteoglycan biosynthetic process |
|
GO:0030168 |
platelet activation |
|
GO:0030879 |
mammary gland development |
|
GO:0031017 |
exocrine pancreas development |
|
GO:0031093 |
platelet alpha granule lumen |
|
GO:0032878 |
regulation of establishment or maintenance of cell polarity |
|
GO:0034392 |
negative regulation of smooth muscle cell apoptosis |
|
GO:0035630 |
bone mineralization involved in bone maturation |
|
GO:0040014 |
regulation of multicellular organism growth |
|
GO:0042104 |
positive regulation of activated T cell proliferation |
|
GO:0042523 |
positive regulation of tyrosine phosphorylation of Stat5 protein |
|
GO:0043568 |
positive regulation of insulin-like growth factor receptor signaling pathway |
|
GO:0045445 |
myoblast differentiation |
|
GO:0045669 |
positive regulation of osteoblast differentiation |
|
GO:0045725 |
positive regulation of glycogen biosynthetic process |
|
GO:0045740 |
positive regulation of DNA replication |
|
GO:0045821 |
positive regulation of glycolysis |
|
GO:0045840 |
positive regulation of mitosis |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046326 |
positive regulation of glucose import |
|
GO:0046579 |
positive regulation of Ras protein signal transduction |
|
GO:0048015 |
phosphatidylinositol-mediated signaling |
|
GO:0048146 |
positive regulation of fibroblast proliferation |
|
GO:0048286 |
lung alveolus development |
|
GO:0048661 |
positive regulation of smooth muscle cell proliferation |
|
GO:0048754 |
branching morphogenesis of a tube |
|
GO:0050650 |
chondroitin sulfate proteoglycan biosynthetic process |
|
GO:0050679 |
positive regulation of epithelial cell proliferation |
|
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
|
GO:0051246 |
regulation of protein metabolic process |
|
GO:0051450 |
myoblast proliferation |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0060426 |
lung vasculature development |
|
GO:0060463 |
lung lobe morphogenesis |
|
GO:0060509 |
Type I pneumocyte differentiation |
|
GO:0060510 |
Type II pneumocyte differentiation |
|
GO:0060527 |
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
|
GO:0060736 |
prostate gland growth |
|
GO:0060740 |
prostate gland epithelium morphogenesis |
|
GO:0060741 |
prostate gland stromal morphogenesis |
|
GO:0060766 |
negative regulation of androgen receptor signaling pathway |
|
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
