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Gene basic information

LiverAtlas Gene ID	HuLG002349
Entrez Gene ID	3481
Official Gene Symbol	IGF2
Synonyms	C11orf43\|FLJ22066\|FLJ44734\|IGFNII\|PP9974
Gene name	insulin-like growth factor 2 (somatomedin A)
Gene Type	protein-coding
Chromosome	11
Genomics Location	11p15.5
Known cancer genes	Yes
Protein products	Insulin-like growth factor 2 Uncharacterized protein Insulin-like growth factor II transcript variant 3 isoform 2 Insulin-like growth factor II transcript variant 3 isoform 1 Insulin-like growth factor II
Related liver disease name	Hepatitis Viral hepatitis Hepatitis A Hepatitis B Chronic hepatitis B Hepatitis C Hepatitis D Hepatitis E Chronic hepatitis Drug-induced hepatitis Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Hepatocellular carcinoma
Database cross reference	HGNC:5466 MIM:147470 Ensembl:ENSG00000167244 HPRD:00939 HPRD:17410 RefSeq Genomic nucleotide accession:AC_000054 RefSeq Genomic nucleotide gi:89161188

Liver relevance

HCC significant genes	Yes/No	Yes
	Evidence	EHCO HCC.net OncoDB
	Quality score

Ontology annotation

GO ID	GO annotation
GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001934	positive regulation of protein phosphorylation
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006355	regulation of transcription, DNA-dependent
GO:0007275	multicellular organismal development
GO:0008083	growth factor activity
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0030546	receptor activator activity
GO:0035558	phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling
GO:0042104	positive regulation of activated T cell proliferation
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPKKK cascade
GO:0043539	protein serine/threonine kinase activator activity
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling cascade
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:2000273	positive regulation of receptor activity
GO:2000467	positive regulation of glycogen (starch) synthase activity