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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002390

Entrez Gene ID

3566

Official Gene Symbol

IL4R

Synonyms

CD124|IL4RA

Gene name

interleukin 4 receptor

Gene Type

protein-coding

Chromosome

16

Genomics Location

16p12.1-p11.2

Known cancer genes

Yes

Protein products

Interleukin 4 receptor

Interleukin-4 receptor subunit alpha

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Drug-induced hepatitis

Hepatocellular carcinoma

Database cross reference

HGNC:6015
MIM:147781
Ensembl:ENSG00000077238
HPRD:00990
RefSeq Genomic nucleotide accession:AC_000059
RefSeq Genomic nucleotide gi:89161194

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0002532

production of molecular mediator involved in inflammatory response

GO:0004872

receptor activity

GO:0004913

interleukin-4 receptor activity

GO:0005057

receptor signaling protein activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006955

immune response

GO:0007165

signal transduction

GO:0035771

interleukin-4-mediated signaling pathway

GO:0042127

regulation of cell proliferation

GO:0042802

identical protein binding

GO:0043032

positive regulation of macrophage activation

GO:0043560

insulin receptor substrate binding

GO:0045626

negative regulation of T-helper 1 cell differentiation

GO:0045630

positive regulation of T-helper 2 cell differentiation

GO:0090197

positive regulation of chemokine secretion