HuLG002394

Entrez Gene ID

3570

Official Gene Symbol

IL6R

Synonyms

CD126|ILN6RN1|ILN6RA|IL6RA|MGC104991|gp80

Gene name

interleukin 6 receptor

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q21

Known cancer genes

Yes

Protein products

Interleukin 6 receptor

Interleukin-6 receptor subunit alpha

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:6019
MIM:147880
Ensembl:ENSG00000160712
HPRD:01000
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0002384

hepatic immune response

GO:0002446

neutrophil mediated immunity

GO:0002548

monocyte chemotaxis

GO:0002690

positive regulation of leukocyte chemotaxis

GO:0004872

receptor activity

GO:0004897

ciliary neurotrophic factor receptor activity

GO:0004915

interleukin-6 receptor activity

GO:0005138

interleukin-6 receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005886

plasma membrane

GO:0005896

interleukin-6 receptor complex

GO:0006953

acute-phase response

GO:0008284

positive regulation of cell proliferation

GO:0009986

cell surface

GO:0010332

response to gamma radiation

GO:0010536

positive regulation of activation of Janus kinase activity

GO:0016021

integral to membrane

GO:0016323

basolateral plasma membrane

GO:0016324

apical plasma membrane

GO:0019221

cytokine-mediated signaling pathway

GO:0019899

enzyme binding

GO:0019981

interleukin-6 binding

GO:0031018

endocrine pancreas development

GO:0032496

response to lipopolysaccharide

GO:0032717

negative regulation of interleukin-8 production

GO:0032722

positive regulation of chemokine production

GO:0032755

positive regulation of interleukin-6 production

GO:0032966

negative regulation of collagen biosynthetic process

GO:0034097

response to cytokine stimulus

GO:0042517

positive regulation of tyrosine phosphorylation of Stat3 protein

GO:0042803

protein homodimerization activity

GO:0042981

regulation of apoptosis

GO:0043410

positive regulation of MAPKKK cascade

GO:0043434

response to peptide hormone stimulus

GO:0045471

response to ethanol

GO:0045669

positive regulation of osteoblast differentiation

GO:0045768

positive regulation of anti-apoptosis

GO:0048661

positive regulation of smooth muscle cell proliferation

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO:0050829

defense response to Gram-negative bacterium

GO:0050830

defense response to Gram-positive bacterium

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051384

response to glucocorticoid stimulus

GO:0051591

response to cAMP

GO:0070102

interleukin-6-mediated signaling pathway

GO:0070119

ciliary neurotrophic factor binding

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway