Gene basic information
| LiverAtlas Gene ID |
HuLG002395 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
IL6ST |
|
Synonyms |
CD130|CDW130|DKFZp564F053|GP130|ILN6RB |
|
Gene name |
interleukin 6 signal transducer (gp130, oncostatin M receptor) |
|
Gene Type |
protein-coding |
|
Chromosome |
5 |
|
Genomics Location |
5q11 |
|
Known cancer genes |
Yes |
|
Protein products |
Interleukin-6 receptor subunit beta Interleukin 6 signal transducer (Gp130, oncostatin M receptor) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6021
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0002675 |
positive regulation of acute inflammatory response |
|
GO:0002821 |
positive regulation of adaptive immune response |
|
GO:0004872 |
receptor activity |
|
GO:0004897 |
ciliary neurotrophic factor receptor activity |
|
GO:0004915 |
interleukin-6 receptor activity |
|
GO:0004923 |
leukemia inhibitory factor receptor activity |
|
GO:0004924 |
oncostatin-M receptor activity |
|
GO:0005127 |
ciliary neurotrophic factor receptor binding |
|
GO:0005138 |
interleukin-6 receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005576 |
extracellular region |
|
GO:0005615 |
extracellular space |
|
GO:0005886 |
plasma membrane |
|
GO:0005896 |
interleukin-6 receptor complex |
|
GO:0005900 |
oncostatin-M receptor complex |
|
GO:0006642 |
triglyceride mobilization |
|
GO:0007259 |
JAK-STAT cascade |
|
GO:0007584 |
response to nutrient |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0010575 |
positive regulation vascular endothelial growth factor production |
|
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
|
GO:0014911 |
positive regulation of smooth muscle cell migration |
|
GO:0016021 |
integral to membrane |
|
GO:0019221 |
cytokine-mediated signaling pathway |
|
GO:0019838 |
growth factor binding |
|
GO:0019981 |
interleukin-6 binding |
|
GO:0034097 |
response to cytokine stimulus |
|
GO:0042102 |
positive regulation of T cell proliferation |
|
GO:0042511 |
positive regulation of tyrosine phosphorylation of Stat1 protein |
|
GO:0042517 |
positive regulation of tyrosine phosphorylation of Stat3 protein |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0045509 |
interleukin-27 receptor activity |
|
GO:0045669 |
positive regulation of osteoblast differentiation |
|
GO:0045768 |
positive regulation of anti-apoptosis |
|
GO:0048861 |
leukemia inhibitory factor signaling pathway |
|
GO:0051481 |
reduction of cytosolic calcium ion concentration |
|
GO:0070102 |
interleukin-6-mediated signaling pathway |
|
GO:0070104 |
negative regulation of interleukin-6-mediated signaling pathway |
|
GO:0070106 |
interleukin-27-mediated signaling pathway |
|
GO:0070110 |
ciliary neurotrophic factor receptor complex |
|
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
