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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002408

Entrez Gene ID

3592

Official Gene Symbol

IL12A

Synonyms

CLMF|ILN12A|NFSK|NKSF1|P35

Gene name

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

Gene Type

protein-coding

Chromosome

3

Genomics Location

3q25.33-q26

Protein products

Interleukin-12 subunit alpha

Interleukin 12

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Biliary cirrhosis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:5969
MIM:161560
Ensembl:ENSG00000168811
HPRD:01193
RefSeq Genomic nucleotide accession:AC_000046
RefSeq Genomic nucleotide gi:89161204

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001916

positive regulation of T cell mediated cytotoxicity

GO:0002860

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

GO:0005125

cytokine activity

GO:0005143

interleukin-12 receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005737

cytoplasm

GO:0006955

immune response

GO:0007050

cell cycle arrest

GO:0008083

growth factor activity

GO:0009615

response to virus

GO:0010224

response to UV-B

GO:0016477

cell migration

GO:0032496

response to lipopolysaccharide

GO:0032700

negative regulation of interleukin-17 production

GO:0032729

positive regulation of interferon-gamma production

GO:0032816

positive regulation of natural killer cell activation

GO:0034393

positive regulation of smooth muscle cell apoptosis

GO:0042102

positive regulation of T cell proliferation

GO:0042163

interleukin-12 beta subunit binding

GO:0042520

positive regulation of tyrosine phosphorylation of Stat4 protein

GO:0042832

defense response to protozoan

GO:0043514

interleukin-12 complex

GO:0045513

interleukin-27 binding

GO:0045785

positive regulation of cell adhesion

GO:0045954

positive regulation of natural killer cell mediated cytotoxicity

GO:0046982

protein heterodimerization activity

GO:0048662

negative regulation of smooth muscle cell proliferation

GO:0050671

positive regulation of lymphocyte proliferation

GO:0050830

defense response to Gram-positive bacterium

GO:0051135

positive regulation of NK T cell activation