Gene basic information
LiverAtlas Gene ID |
HuLG002408 |
Entrez Gene ID |
|
Official Gene Symbol |
IL12A |
Synonyms |
CLMF|ILN12A|NFSK|NKSF1|P35 |
Gene name |
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) |
Gene Type |
protein-coding |
Chromosome |
3 |
Genomics Location |
3q25.33-q26 |
Protein products |
|
Related liver disease name |
|
Database cross reference |
HGNC:5969
|
Liver relevance
HCC significant genes |
Yes/No |
Yes |
Evidence |
EHCO |
|
Quality score |
|
Ontology annotation
GO ID |
GO annotation |
GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
GO:0002860 |
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target |
GO:0005125 |
cytokine activity |
GO:0005143 |
interleukin-12 receptor binding |
GO:0005515 |
protein binding |
GO:0005576 |
extracellular region |
GO:0005615 |
extracellular space |
GO:0005737 |
cytoplasm |
GO:0006955 |
immune response |
GO:0007050 |
cell cycle arrest |
GO:0008083 |
growth factor activity |
GO:0009615 |
response to virus |
GO:0010224 |
response to UV-B |
GO:0016477 |
cell migration |
GO:0032496 |
response to lipopolysaccharide |
GO:0032700 |
negative regulation of interleukin-17 production |
GO:0032729 |
positive regulation of interferon-gamma production |
GO:0032816 |
positive regulation of natural killer cell activation |
GO:0034393 |
positive regulation of smooth muscle cell apoptosis |
GO:0042102 |
positive regulation of T cell proliferation |
GO:0042163 |
interleukin-12 beta subunit binding |
GO:0042520 |
positive regulation of tyrosine phosphorylation of Stat4 protein |
GO:0042832 |
defense response to protozoan |
GO:0043514 |
interleukin-12 complex |
GO:0045513 |
interleukin-27 binding |
GO:0045785 |
positive regulation of cell adhesion |
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
GO:0046982 |
protein heterodimerization activity |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
GO:0050671 |
positive regulation of lymphocyte proliferation |
GO:0050830 |
defense response to Gram-positive bacterium |
GO:0051135 |
positive regulation of NK T cell activation |