HuLG002440

Entrez Gene ID

3630

Official Gene Symbol

INS

Synonyms

IDDM2|ILPR|IRDN|MODY10

Gene name

insulin

Gene Type

protein-coding

Chromosome

11

Genomics Location

11p15.5

Known cancer genes

Yes

Protein products

Insulin

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Primary sclerosing cholangitis

Database cross reference

HGNC:6081
MIM:176730
Ensembl:ENSG00000129965
Ensembl:ENSG00000254647
HPRD:01455
RefSeq Genomic nucleotide accession:AC_000054
RefSeq Genomic nucleotide gi:89161188

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0000165

MAPKKK cascade

GO:0002674

negative regulation of acute inflammatory response

GO:0005158

insulin receptor binding

GO:0005159

insulin-like growth factor receptor binding

GO:0005179

hormone activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005788

endoplasmic reticulum lumen

GO:0005975

carbohydrate metabolic process

GO:0006006

glucose metabolic process

GO:0006112

energy reserve metabolic process

GO:0006355

regulation of transcription, DNA-dependent

GO:0006521

regulation of cellular amino acid metabolic process

GO:0006953

acute-phase response

GO:0007186

G-protein coupled receptor protein signaling pathway

GO:0007267

cell-cell signaling

GO:0008284

positive regulation of cell proliferation

GO:0008286

insulin receptor signaling pathway

GO:0008543

fibroblast growth factor receptor signaling pathway

GO:0014068

positive regulation of phosphatidylinositol 3-kinase cascade

GO:0015758

glucose transport

GO:0022898

regulation of transmembrane transporter activity

GO:0030307

positive regulation of cell growth

GO:0030335

positive regulation of cell migration

GO:0031018

endocrine pancreas development

GO:0031904

endosome lumen

GO:0031954

positive regulation of protein autophosphorylation

GO:0032148

activation of protein kinase B activity

GO:0032270

positive regulation of cellular protein metabolic process

GO:0032880

regulation of protein localization

GO:0033861

negative regulation of NAD(P)H oxidase activity

GO:0042060

wound healing

GO:0042177

negative regulation of protein catabolic process

GO:0042593

glucose homeostasis

GO:0043066

negative regulation of apoptosis

GO:0043410

positive regulation of MAPKKK cascade

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO:0045597

positive regulation of cell differentiation

GO:0045721

negative regulation of gluconeogenesis

GO:0045725

positive regulation of glycogen biosynthetic process

GO:0045740

positive regulation of DNA replication

GO:0045818

negative regulation of glycogen catabolic process

GO:0045821

positive regulation of glycolysis

GO:0045840

positive regulation of mitosis

GO:0045861

negative regulation of proteolysis

GO:0045908

negative regulation of vasodilation

GO:0045909

positive regulation of vasodilation

GO:0045922

negative regulation of fatty acid metabolic process

GO:0046326

positive regulation of glucose import

GO:0046628

positive regulation of insulin receptor signaling pathway

GO:0046631

alpha-beta T cell activation

GO:0046889

positive regulation of lipid biosynthetic process

GO:0050708

regulation of protein secretion

GO:0050709

negative regulation of protein secretion

GO:0050715

positive regulation of cytokine secretion

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO:0050796

regulation of insulin secretion

GO:0050995

negative regulation of lipid catabolic process

GO:0051000

positive regulation of nitric-oxide synthase activity

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051897

positive regulation of protein kinase B signaling cascade

GO:0055089

fatty acid homeostasis

GO:0060266

negative regulation of respiratory burst involved in inflammatory response

GO:0060267

positive regulation of respiratory burst

GO:2000252

negative regulation of feeding behavior