Gene basic information
| LiverAtlas Gene ID |
HuLG002450 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
INSR |
|
Synonyms |
CD220|HHF5 |
|
Gene name |
insulin receptor |
|
Gene Type |
protein-coding |
|
Chromosome |
19 |
|
Genomics Location |
19p13.3-p13.2 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6091
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000166 |
nucleotide binding |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0001933 |
negative regulation of protein phosphorylation |
|
GO:0001934 |
positive regulation of protein phosphorylation |
|
GO:0003007 |
heart morphogenesis |
|
GO:0004713 |
protein tyrosine kinase activity |
|
GO:0004716 |
receptor signaling protein tyrosine kinase activity |
|
GO:0004872 |
receptor activity |
|
GO:0005009 |
insulin receptor activity |
|
GO:0005159 |
insulin-like growth factor receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005525 |
GTP binding |
|
GO:0005625 |
soluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005768 |
endosome |
|
GO:0005792 |
microsome |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0005887 |
integral to plasma membrane |
|
GO:0005899 |
insulin receptor complex |
|
GO:0005901 |
caveola |
|
GO:0005975 |
carbohydrate metabolic process |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0007186 |
G-protein coupled receptor protein signaling pathway |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008286 |
insulin receptor signaling pathway |
|
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
|
GO:0009725 |
response to hormone stimulus |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0010008 |
endosome membrane |
|
GO:0010042 |
response to manganese ion |
|
GO:0010310 |
regulation of hydrogen peroxide metabolic process |
|
GO:0010560 |
positive regulation of glycoprotein biosynthetic process |
|
GO:0010629 |
negative regulation of gene expression |
|
GO:0014823 |
response to activity |
|
GO:0016020 |
membrane |
|
GO:0018108 |
peptidyl-tyrosine phosphorylation |
|
GO:0019087 |
transformation of host cell by virus |
|
GO:0019903 |
protein phosphatase binding |
|
GO:0030238 |
male sex determination |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0031017 |
exocrine pancreas development |
|
GO:0031405 |
lipoic acid binding |
|
GO:0031667 |
response to nutrient levels |
|
GO:0031994 |
insulin-like growth factor I binding |
|
GO:0031995 |
insulin-like growth factor II binding |
|
GO:0032147 |
activation of protein kinase activity |
|
GO:0032148 |
activation of protein kinase B activity |
|
GO:0032355 |
response to estradiol stimulus |
|
GO:0032403 |
protein complex binding |
|
GO:0032410 |
negative regulation of transporter activity |
|
GO:0032869 |
cellular response to insulin stimulus |
|
GO:0033280 |
response to vitamin D |
|
GO:0033574 |
response to testosterone stimulus |
|
GO:0034612 |
response to tumor necrosis factor |
|
GO:0042169 |
SH2 domain binding |
|
GO:0042593 |
glucose homeostasis |
|
GO:0043410 |
positive regulation of MAPKKK cascade |
|
GO:0043423 |
3-phosphoinositide-dependent protein kinase binding |
|
GO:0043548 |
phosphatidylinositol 3-kinase binding |
|
GO:0043559 |
insulin binding |
|
GO:0043560 |
insulin receptor substrate binding |
|
GO:0045202 |
synapse |
|
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
|
GO:0045444 |
fat cell differentiation |
|
GO:0045471 |
response to ethanol |
|
GO:0045725 |
positive regulation of glycogen biosynthetic process |
|
GO:0045740 |
positive regulation of DNA replication |
|
GO:0045821 |
positive regulation of glycolysis |
|
GO:0045840 |
positive regulation of mitosis |
|
GO:0045995 |
regulation of embryonic development |
|
GO:0046326 |
positive regulation of glucose import |
|
GO:0046777 |
protein autophosphorylation |
|
GO:0046872 |
metal ion binding |
|
GO:0048639 |
positive regulation of developmental growth |
|
GO:0051290 |
protein heterotetramerization |
|
GO:0051384 |
response to glucocorticoid stimulus |
|
GO:0051425 |
PTB domain binding |
|
GO:0051789 |
response to protein stimulus |
|
GO:0051897 |
positive regulation of protein kinase B signaling cascade |
|
GO:0060267 |
positive regulation of respiratory burst |
|
GO:0071363 |
cellular response to growth factor stimulus |
