Gene basic information
| LiverAtlas Gene ID |
HuLG002462 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
IRF3 |
|
Gene name |
interferon regulatory factor 3 |
|
Gene Type |
protein-coding |
|
Chromosome |
19 |
|
Genomics Location |
19q13.3-q13.4 |
|
Known cancer genes |
Yes |
|
Protein products |
Interferon regulatory factor 3a Interferon regulatory factor 3b Interferon regulatory factor 3c Interferon regulatory factor 3d Interferon regulatory factor 3e Interferon regulatory factor 3 Interferon regulatory factor 3 nirs variant 3 Interferon regulatory factor 3 nirs variant 2 Interferon regulatory factor 3 nirs variant 1 |
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis C infection |
|
Database cross reference |
HGNC:6118
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0002756 |
MyD88-independent toll-like receptor signaling pathway |
|
GO:0003677 |
DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0003712 |
transcription cofactor activity |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006366 |
transcription from RNA polymerase II promoter |
|
GO:0008063 |
Toll signaling pathway |
|
GO:0009615 |
response to virus |
|
GO:0009617 |
response to bacterium |
|
GO:0010008 |
endosome membrane |
|
GO:0019221 |
cytokine-mediated signaling pathway |
|
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
|
GO:0032480 |
negative regulation of type I interferon production |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0034138 |
toll-like receptor 3 signaling pathway |
|
GO:0034142 |
toll-like receptor 4 signaling pathway |
|
GO:0042802 |
identical protein binding |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043330 |
response to exogenous dsRNA |
|
GO:0044419 |
interspecies interaction between organisms |
|
GO:0045087 |
innate immune response |
|
GO:0045351 |
type I interferon biosynthetic process |
|
GO:0045358 |
negative regulation of interferon-beta biosynthetic process |
|
GO:0050689 |
negative regulation of defense response to virus by host |
|
GO:0060333 |
interferon-gamma-mediated signaling pathway |
|
GO:0060337 |
type I interferon-mediated signaling pathway |
