Gene basic information
| LiverAtlas Gene ID |
HuLG002467 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
IRS1 |
|
Synonyms |
HIRSN1 |
|
Gene name |
insulin receptor substrate 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
2 |
|
Genomics Location |
2q36 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6125
|
Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
|
Evidence |
Translational level from literatures |
|
|
Quality score |
|
|
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0002053 |
positive regulation of mesenchymal cell proliferation |
|
GO:0004871 |
signal transducer activity |
|
GO:0005010 |
insulin-like growth factor receptor activity |
|
GO:0005068 |
transmembrane receptor protein tyrosine kinase adaptor activity |
|
GO:0005080 |
protein kinase C binding |
|
GO:0005158 |
insulin receptor binding |
|
GO:0005159 |
insulin-like growth factor receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005792 |
microsome |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0005899 |
insulin receptor complex |
|
GO:0005901 |
caveola |
|
GO:0007165 |
signal transduction |
|
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
|
GO:0008284 |
positive regulation of cell proliferation |
|
GO:0008286 |
insulin receptor signaling pathway |
|
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
|
GO:0010468 |
regulation of gene expression |
|
GO:0010907 |
positive regulation of glucose metabolic process |
|
GO:0014065 |
phosphatidylinositol 3-kinase cascade |
|
GO:0016042 |
lipid catabolic process |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030879 |
mammary gland development |
|
GO:0032000 |
positive regulation of fatty acid beta-oxidation |
|
GO:0032868 |
response to insulin stimulus |
|
GO:0032869 |
cellular response to insulin stimulus |
|
GO:0042169 |
SH2 domain binding |
|
GO:0042327 |
positive regulation of phosphorylation |
|
GO:0042593 |
glucose homeostasis |
|
GO:0043434 |
response to peptide hormone stimulus |
|
GO:0043491 |
protein kinase B signaling cascade |
|
GO:0043548 |
phosphatidylinositol 3-kinase binding |
|
GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity |
|
GO:0045725 |
positive regulation of glycogen biosynthetic process |
|
GO:0046326 |
positive regulation of glucose import |
|
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
|
GO:0046628 |
positive regulation of insulin receptor signaling pathway |
|
GO:0046676 |
negative regulation of insulin secretion |
|
GO:0048009 |
insulin-like growth factor receptor signaling pathway |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048015 |
phosphatidylinositol-mediated signaling |
|
GO:0051291 |
protein heterooligomerization |
|
GO:0070094 |
positive regulation of glucagon secretion |
|
GO:0090275 |
negative regulation of somatostatin secretion |
