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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002483

Entrez Gene ID

3685

Official Gene Symbol

ITGAV

Synonyms

CD51|DKFZp686A08142|MSK8|VNRA

Gene name

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q31-q32

Known cancer genes

Yes

Protein products

ITGAV protein

cDNA FLJ51414, highly similar to Integrin alpha-V

ITGAV protein

Integrin alpha-V

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Biliary cirrhosis

Hepatocellular carcinoma

Database cross reference

HGNC:6150
MIM:193210
Ensembl:ENSG00000138448
HPRD:01903
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001525

angiogenesis

GO:0001568

blood vessel development

GO:0001846

opsonin binding

GO:0004872

receptor activity

GO:0005515

protein binding

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0007155

cell adhesion

GO:0007160

cell-matrix adhesion

GO:0007229

integrin-mediated signaling pathway

GO:0007411

axon guidance

GO:0007596

blood coagulation

GO:0008284

positive regulation of cell proliferation

GO:0008305

integrin complex

GO:0009897

external side of plasma membrane

GO:0009986

cell surface

GO:0010745

negative regulation of macrophage derived foam cell differentiation

GO:0010888

negative regulation of lipid storage

GO:0016020

membrane

GO:0031994

insulin-like growth factor I binding

GO:0032369

negative regulation of lipid transport

GO:0035635

entry of bacterium into host cell

GO:0043066

negative regulation of apoptosis

GO:0044419

interspecies interaction between organisms

GO:0045715

negative regulation of low-density lipoprotein particle receptor biosynthetic process

GO:0045785

positive regulation of cell adhesion

GO:0046718

entry of virus into host cell

GO:0050431

transforming growth factor beta binding

GO:0050748

negative regulation of lipoprotein metabolic process

GO:0050764

regulation of phagocytosis

GO:0050900

leukocyte migration

GO:0052066

entry of symbiont into host cell by promotion of host phagocytosis

GO:0070371

ERK1 and ERK2 cascade

GO:0097024

protein kinase C alpha binding

GO:2000425

regulation of apoptotic cell clearance