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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002666

Entrez Gene ID

3931

Official Gene Symbol

LCAT

Gene name

lecithin-cholesterol acyltransferase

Gene Type

protein-coding

Chromosome

16

Genomics Location

16q22.1

Protein products

Phosphatidylcholine-sterol acyltransferase

Lecithin-cholesterol acyltransferase

Related liver disease name

Liver fibrosis and liver cirrhosis

Viral hepatitis

Alcoholic liver cirrhosis

Hepatocellular carcinoma

Database cross reference

HGNC:6522
MIM:606967
Ensembl:ENSG00000213398
HPRD:06098
RefSeq Genomic nucleotide accession:AC_000059
RefSeq Genomic nucleotide gi:89161194

Liver relevance

Liver sepcificity

Yes/No

Yes

Evidence

Translational level from literatures

Quality score

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0004607

phosphatidylcholine-sterol O-acyltransferase activity

GO:0004623

phospholipase A2 activity

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0006629

lipid metabolic process

GO:0006644

phospholipid metabolic process

GO:0006656

phosphatidylcholine biosynthetic process

GO:0008202

steroid metabolic process

GO:0008203

cholesterol metabolic process

GO:0016740

transferase activity

GO:0030301

cholesterol transport

GO:0034186

apolipoprotein A-I binding

GO:0034364

high-density lipoprotein particle

GO:0034372

very-low-density lipoprotein particle remodeling

GO:0034375

high-density lipoprotein particle remodeling

GO:0034435

cholesterol esterification

GO:0042157

lipoprotein metabolic process

GO:0042158

lipoprotein biosynthetic process

GO:0042632

cholesterol homeostasis

GO:0043691

reverse cholesterol transport

GO:0046688

response to copper ion

GO:0051384

response to glucocorticoid stimulus