HuLG002742

Entrez Gene ID

4049

Official Gene Symbol

LTA

Synonyms

LT|TNFB|TNFSF1

Gene name

lymphotoxin alpha (TNF superfamily, member 1)

Gene Type

protein-coding

Chromosome

6

Genomics Location

6p21.3

Known cancer genes

Yes

Protein products

Lymphotoxin alpha transcript variant 3

Lymphotoxin alpha (TNF superfamily, member 1)

LTA protein

Lymphotoxin-alpha

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Autoimmune hepatitis

Primary biliary cirrhosis

Database cross reference

HGNC:6709
MIM:153440
Ensembl:ENSG00000226979
HPRD:01084
RefSeq Genomic nucleotide accession:AC_000049
RefSeq Genomic nucleotide gi:89161209

GO annotation

GO:0001666

response to hypoxia

GO:0002876

positive regulation of chronic inflammatory response to antigenic stimulus

GO:0002925

positive regulation of humoral immune response mediated by circulating immunoglobulin

GO:0005102

receptor binding

GO:0005125

cytokine activity

GO:0005164

tumor necrosis factor receptor binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0006917

induction of apoptosis

GO:0006959

humoral immune response

GO:0007165

signal transduction

GO:0007267

cell-cell signaling

GO:0007584

response to nutrient

GO:0016020

membrane

GO:0032496

response to lipopolysaccharide

GO:0032729

positive regulation of interferon-gamma production

GO:0042493

response to drug

GO:0044130

negative regulation of growth of symbiont in host

GO:0048147

negative regulation of fibroblast proliferation

GO:0048535

lymph node development

GO:0050830

defense response to Gram-positive bacterium