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Gene basic information

LiverAtlas Gene ID

HuLG002773

Entrez Gene ID

4086

Official Gene Symbol

SMAD1

Synonyms

BSP1|JV4N1|JV41|MADH1|MADR1

Gene name

SMAD family member 1

Gene Type

protein-coding

Chromosome

4

Genomics Location

4q31

Known cancer genes

Yes

Protein products

Mothers against decapentaplegic homolog 1

Database cross reference

HGNC:6767
MIM:601595
Ensembl:ENSG00000170365
HPRD:03356
RefSeq Genomic nucleotide accession:AC_000047
RefSeq Genomic nucleotide gi:89161206

 

Ontology annotation

GO ID

GO annotation

GO:0000165

MAPKKK cascade

GO:0001657

ureteric bud development

GO:0001710

mesodermal cell fate commitment

GO:0001822

kidney development

GO:0002051

osteoblast fate commitment

GO:0003700

sequence-specific DNA binding transcription factor activity

GO:0005057

receptor signaling protein activity

GO:0005515

protein binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005637

nuclear inner membrane

GO:0005654

nucleoplasm

GO:0005667

transcription factor complex

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006351

transcription, DNA-dependent

GO:0006468

protein phosphorylation

GO:0006954

inflammatory response

GO:0007165

signal transduction

GO:0007179

transforming growth factor beta receptor signaling pathway

GO:0007183

SMAD protein complex assembly

GO:0007276

gamete generation

GO:0008285

negative regulation of cell proliferation

GO:0009880

embryonic pattern specification

GO:0010243

response to organic nitrogen

GO:0010628

positive regulation of gene expression

GO:0016021

integral to membrane

GO:0019901

protein kinase binding

GO:0030509

BMP signaling pathway

GO:0030618

transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

GO:0030901

midbrain development

GO:0030902

hindbrain development

GO:0031053

primary microRNA processing

GO:0042060

wound healing

GO:0042493

response to drug

GO:0042592

homeostatic process

GO:0042802

identical protein binding

GO:0045669

positive regulation of osteoblast differentiation

GO:0045768

positive regulation of anti-apoptosis

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0050775

positive regulation of dendrite morphogenesis

GO:0061036

positive regulation of cartilage development

GO:0070410

co-SMAD binding

GO:0070411

I-SMAD binding

GO:0071407

cellular response to organic cyclic compound