Gene basic information
| LiverAtlas Gene ID |
HuLG002775 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMAD3 |
|
Synonyms |
DKFZp586N0721|DKFZp686J10186|HSPC193|HsT17436|JV15N2|MADH3|MGC60396 |
|
Gene name |
SMAD family member 3 |
|
Gene Type |
protein-coding |
|
Chromosome |
15 |
|
Genomics Location |
15q22.33 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ54532, highly similar to Mothers against decapentaplegic homolog 3 (SMAD3) cDNA, FLJ78916, highly similar to Mothers against decapentaplegic homolog 3 (SMAD3) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6769
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001102 |
RNA polymerase II activating transcription factor binding |
|
GO:0001501 |
skeletal system development |
|
GO:0001657 |
ureteric bud development |
|
GO:0001666 |
response to hypoxia |
|
GO:0001701 |
in utero embryonic development |
|
GO:0001707 |
mesoderm formation |
|
GO:0001756 |
somitogenesis |
|
GO:0001836 |
release of cytochrome c from mitochondria |
|
GO:0001889 |
liver development |
|
GO:0001933 |
negative regulation of protein phosphorylation |
|
GO:0001947 |
heart looping |
|
GO:0002076 |
osteoblast development |
|
GO:0002520 |
immune system development |
|
GO:0003690 |
double-stranded DNA binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0003706 |
ligand-regulated transcription factor activity |
|
GO:0005160 |
transforming growth factor beta receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005518 |
collagen binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005637 |
nuclear inner membrane |
|
GO:0005654 |
nucleoplasm |
|
GO:0005667 |
transcription factor complex |
|
GO:0005737 |
cytoplasm |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0006810 |
transport |
|
GO:0006917 |
induction of apoptosis |
|
GO:0006919 |
activation of caspase activity |
|
GO:0006955 |
immune response |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0007183 |
SMAD protein complex assembly |
|
GO:0007369 |
gastrulation |
|
GO:0007492 |
endoderm development |
|
GO:0008013 |
beta-catenin binding |
|
GO:0008134 |
transcription factor binding |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008633 |
activation of pro-apoptotic gene products |
|
GO:0009880 |
embryonic pattern specification |
|
GO:0010694 |
positive regulation of alkaline phosphatase activity |
|
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
|
GO:0016202 |
regulation of striated muscle tissue development |
|
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0019049 |
evasion of host defenses by virus |
|
GO:0019901 |
protein kinase binding |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030501 |
positive regulation of bone mineralization |
|
GO:0030618 |
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
|
GO:0030878 |
thyroid gland development |
|
GO:0031053 |
primary microRNA processing |
|
GO:0031625 |
ubiquitin protein ligase binding |
|
GO:0032731 |
positive regulation of interleukin-1 beta production |
|
GO:0032909 |
regulation of transforming growth factor-beta2 production |
|
GO:0032916 |
positive regulation of transforming growth factor-beta3 production |
|
GO:0035413 |
positive regulation of catenin import into nucleus |
|
GO:0042060 |
wound healing |
|
GO:0042110 |
T cell activation |
|
GO:0042177 |
negative regulation of protein catabolic process |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0042993 |
positive regulation of transcription factor import into nucleus |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043235 |
receptor complex |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0045216 |
cell-cell junction organization |
|
GO:0045668 |
negative regulation of osteoblast differentiation |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045930 |
negative regulation of mitotic cell cycle |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0046872 |
metal ion binding |
|
GO:0048340 |
paraxial mesoderm morphogenesis |
|
GO:0048589 |
developmental growth |
|
GO:0048617 |
embryonic foregut morphogenesis |
|
GO:0048701 |
embryonic cranial skeleton morphogenesis |
|
GO:0050678 |
regulation of epithelial cell proliferation |
|
GO:0050776 |
regulation of immune response |
|
GO:0050821 |
protein stabilization |
|
GO:0050927 |
positive regulation of positive chemotaxis |
|
GO:0051098 |
regulation of binding |
|
GO:0051496 |
positive regulation of stress fiber assembly |
|
GO:0051894 |
positive regulation of focal adhesion assembly |
|
GO:0060039 |
pericardium development |
|
GO:0060290 |
transdifferentiation |
|
GO:0070306 |
lens fiber cell differentiation |
|
GO:0070410 |
co-SMAD binding |
|
GO:0070412 |
R-SMAD binding |
|
GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
