Gene basic information
| LiverAtlas Gene ID |
HuLG002776 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMAD4 |
|
Synonyms |
DPC4|JIP|MADH4 |
|
Gene name |
SMAD family member 4 |
|
Gene Type |
protein-coding |
|
Chromosome |
18 |
|
Genomics Location |
18q21.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6770
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001658 |
branching involved in ureteric bud morphogenesis |
|
GO:0001666 |
response to hypoxia |
|
GO:0001701 |
in utero embryonic development |
|
GO:0001702 |
gastrulation with mouth forming second |
|
GO:0001822 |
kidney development |
|
GO:0003677 |
DNA binding |
|
GO:0003682 |
chromatin binding |
|
GO:0003700 |
sequence-specific DNA binding transcription factor activity |
|
GO:0005515 |
protein binding |
|
GO:0005518 |
collagen binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005667 |
transcription factor complex |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005813 |
centrosome |
|
GO:0005829 |
cytosol |
|
GO:0006351 |
transcription, DNA-dependent |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0007183 |
SMAD protein complex assembly |
|
GO:0007492 |
endoderm development |
|
GO:0007498 |
mesoderm development |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0009952 |
anterior/posterior pattern formation |
|
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
|
GO:0010862 |
positive regulation of pathway-restricted SMAD protein phosphorylation |
|
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0030509 |
BMP signaling pathway |
|
GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0030616 |
transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
|
GO:0032444 |
activin responsive factor complex |
|
GO:0032525 |
somite rostral/caudal axis specification |
|
GO:0032909 |
regulation of transforming growth factor-beta2 production |
|
GO:0042177 |
negative regulation of protein catabolic process |
|
GO:0042802 |
identical protein binding |
|
GO:0042803 |
protein homodimerization activity |
|
GO:0043565 |
sequence-specific DNA binding |
|
GO:0045892 |
negative regulation of transcription, DNA-dependent |
|
GO:0045893 |
positive regulation of transcription, DNA-dependent |
|
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
|
GO:0048589 |
developmental growth |
|
GO:0048663 |
neuron fate commitment |
|
GO:0048729 |
tissue morphogenesis |
|
GO:0048859 |
formation of anatomical boundary |
|
GO:0051098 |
regulation of binding |
|
GO:0060021 |
palate development |
|
GO:0060391 |
positive regulation of SMAD protein import into nucleus |
|
GO:0060395 |
SMAD protein signal transduction |
|
GO:0060548 |
negative regulation of cell death |
|
GO:0070411 |
I-SMAD binding |
|
GO:0070412 |
R-SMAD binding |
|
GO:0071559 |
response to transforming growth factor beta stimulus |
|
GO:0072133 |
metanephric mesenchyme morphogenesis |
|
GO:0072134 |
nephrogenic mesenchyme morphogenesis |
