Gene basic information
| LiverAtlas Gene ID |
HuLG002779 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
SMAD7 |
|
Synonyms |
CRCS3|FLJ16482|MADH7|MADH8 |
|
Gene name |
SMAD family member 7 |
|
Gene Type |
protein-coding |
|
Chromosome |
18 |
|
Genomics Location |
18q21.1 |
|
Known cancer genes |
Yes |
|
Protein products |
cDNA FLJ57868, highly similar to Mothers against decapentaplegic homolog 7 (SMAD 7) |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6773
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
|
GO:0001657 |
ureteric bud development |
|
GO:0005515 |
protein binding |
|
GO:0005518 |
collagen binding |
|
GO:0005622 |
intracellular |
|
GO:0005634 |
nucleus |
|
GO:0005667 |
transcription factor complex |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005813 |
centrosome |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0005913 |
cell-cell adherens junction |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0008013 |
beta-catenin binding |
|
GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
|
GO:0010801 |
negative regulation of peptidyl-threonine phosphorylation |
|
GO:0010944 |
negative regulation of transcription by competitive promoter binding |
|
GO:0016342 |
catenin complex |
|
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0022409 |
positive regulation of cell-cell adhesion |
|
GO:0030336 |
negative regulation of cell migration |
|
GO:0030509 |
BMP signaling pathway |
|
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0030514 |
negative regulation of BMP signaling pathway |
|
GO:0030617 |
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity |
|
GO:0031397 |
negative regulation of protein ubiquitination |
|
GO:0031398 |
positive regulation of protein ubiquitination |
|
GO:0031625 |
ubiquitin protein ligase binding |
|
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
|
GO:0032925 |
regulation of activin receptor signaling pathway |
|
GO:0033137 |
negative regulation of peptidyl-serine phosphorylation |
|
GO:0034333 |
adherens junction assembly |
|
GO:0034616 |
response to laminar fluid shear stress |
|
GO:0034629 |
cellular protein complex localization |
|
GO:0034713 |
type I transforming growth factor beta receptor binding |
|
GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0045768 |
positive regulation of anti-apoptosis |
|
GO:0048185 |
activin binding |
|
GO:0048844 |
artery morphogenesis |
|
GO:0050821 |
protein stabilization |
|
GO:0051444 |
negative regulation of ubiquitin-protein ligase activity |
|
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
|
GO:0055117 |
regulation of cardiac muscle contraction |
|
GO:0060373 |
regulation of ventricular cardiomyocyte membrane depolarization |
|
GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
|
GO:0060394 |
negative regulation of pathway-restricted SMAD protein phosphorylation |
|
GO:0060412 |
ventricular septum morphogenesis |
|
GO:0070411 |
I-SMAD binding |
