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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002841

Entrez Gene ID

4170

Official Gene Symbol

MCL1

Synonyms

BCL2L3|EAT|MCL1NES|MCL1L|MCL1S|MGC104264|MGC1839|MclN1|TM|bcl2NLN3|mcl1/EAT

Gene name

myeloid cell leukemia sequence 1 (BCL2-related)

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q21

Known cancer genes

Yes

Protein products

Myeloid cell leukemia ES variant

Induced myeloid leukemia cell differentiation protein Mcl-1

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:6943
MIM:159552
Ensembl:ENSG00000143384
HPRD:08870
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001709

cell fate determination

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005737

cytoplasm

GO:0005739

mitochondrion

GO:0005741

mitochondrial outer membrane

GO:0005759

mitochondrial matrix

GO:0006915

apoptosis

GO:0006916

anti-apoptosis

GO:0007275

multicellular organismal development

GO:0015266

protein channel activity

GO:0016020

membrane

GO:0016021

integral to membrane

GO:0019725

cellular homeostasis

GO:0030154

cell differentiation

GO:0034097

response to cytokine stimulus

GO:0046982

protein heterodimerization activity

GO:0051434

BH3 domain binding