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Gene basic information

LiverAtlas Gene ID	HuLG002857
Entrez Gene ID	4193
Official Gene Symbol	MDM2
Synonyms	HDMX\|MGC5370\|MGC71221\|hdm2
Gene name	Mdm2 p53 binding protein homolog (mouse)
Gene Type	protein-coding
Chromosome	12
Genomics Location	12q14.3-q15
Known cancer genes	Yes
Protein products	Uncharacterized protein E3 ubiquitin-protein ligase Mdm2 P53-binding protein P53-binding protein p53-binding protein Uncharacterized protein p53-binding protein MDM2 isoform N1 40 protein MDM2 isoform KB9 protein MDM2 protein MDM2 variant FB55 MDM2 variant FB29 MDM2 variant FB26 MDM2 variant FB25 HDM2-HD1 protein Uncharacterized protein P53 binding protein Uncharacterized protein
Related liver disease name	Hepatitis Viral hepatitis Hepatitis A Hepatitis B Chronic hepatitis B Hepatitis C Chronic hepatitis C Hepatitis D Hepatitis E Chronic hepatitis Hepatocellular carcinoma Intrahepatic cholangiocarcinoma Hepatocellular carcinoma
Database cross reference	HGNC:6973 MIM:164785 Ensembl:ENSG00000135679 HPRD:01272 RefSeq Genomic nucleotide accession:AC_000055 RefSeq Genomic nucleotide gi:89161189

Liver relevance

HCC significant genes	Yes/No	Yes
	Evidence	EHCO HCC.net
	Quality score

Ontology annotation

GO ID	GO annotation
GO:0000075	cell cycle checkpoint
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein ligase activity
GO:0005515	protein binding
GO:0005622	intracellular
GO:0005626	insoluble fraction
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0006461	protein complex assembly
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089	traversing start control point of mitotic cell cycle
GO:0007268	synaptic transmission
GO:0008270	zinc ion binding
GO:0008284	positive regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0016604	nuclear body
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0030666	endocytic vesicle membrane
GO:0031648	protein destabilization
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042176	regulation of protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802	identical protein binding
GO:0043066	negative regulation of apoptosis
GO:0043234	protein complex
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044419	interspecies interaction between organisms
GO:0045184	establishment of protein localization
GO:0045931	positive regulation of mitotic cell cycle
GO:0046677	response to antibiotic
GO:0046872	metal ion binding
GO:0048011	nerve growth factor receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0071157	negative regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia