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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002905

Entrez Gene ID

4261

Official Gene Symbol

CIITA

Synonyms

C2TA|CIITAIV|MHC2TA|NLRA

Gene name

class II, major histocompatibility complex, transactivator

Gene Type

protein-coding

Chromosome

16

Genomics Location

16p13

Known cancer genes

Yes

Protein products

Class II, major histocompatibility complex, transactivator

MHC class II transactivator

Uncharacterized protein

CIITA IV

Class II transactivator

MHC class II transactivator type III

Class II, major histocompatibility complex, transactivator, isoform CRA e

MHC2TA

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Chronic hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Primary biliary cirrhosis

Database cross reference

HGNC:7067
MIM:600005
Ensembl:ENSG00000179583
HPRD:02475
RefSeq Genomic nucleotide accession:AC_000059
RefSeq Genomic nucleotide gi:89161194

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0000166

nucleotide binding

GO:0003677

DNA binding

GO:0003713

transcription coactivator activity

GO:0005515

protein binding

GO:0005524

ATP binding

GO:0005634

nucleus

GO:0006355

regulation of transcription, DNA-dependent

GO:0006955

immune response

GO:0008022

protein C-terminus binding

GO:0019221

cytokine-mediated signaling pathway

GO:0032403

protein complex binding

GO:0033613

activating transcription factor binding

GO:0034341

response to interferon-gamma

GO:0045345

positive regulation of MHC class I biosynthetic process

GO:0045348

positive regulation of MHC class II biosynthetic process

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO:0046677

response to antibiotic

GO:0060333

interferon-gamma-mediated signaling pathway