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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG002932

Entrez Gene ID

4311

Official Gene Symbol

MME

Synonyms

CALLA|CD10|DKFZp686O16152|MGC126681|MGC126707|NEP|SFE

Gene name

membrane metallo-endopeptidase

Gene Type

protein-coding

Chromosome

3

Genomics Location

3q25.1-q25.2

Known cancer genes

Yes

Protein products

Membrane metallo-endopeptidase

Neprilysin

MME protein

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:7154
MIM:120520
Ensembl:ENSG00000196549
HPRD:00392
RefSeq Genomic nucleotide accession:AC_000046
RefSeq Genomic nucleotide gi:89161204

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net OncoDB

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0004222

metalloendopeptidase activity

GO:0005515

protein binding

GO:0005624

membrane fraction

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006508

proteolysis

GO:0006518

peptide metabolic process

GO:0007267

cell-cell signaling

GO:0008233

peptidase activity

GO:0008237

metallopeptidase activity

GO:0008270

zinc ion binding

GO:0042277

peptide binding

GO:0046872

metal ion binding