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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG003169

Entrez Gene ID

4771

Official Gene Symbol

NF2

Synonyms

ACN|BANF|SCH

Gene name

neurofibromin 2 (merlin)

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q12.2

Known cancer genes

Yes

Protein products

Merlin

NF2 protein

NF2 protein

NF2 protein

NF2 protein

Neurofibromatosis type 2

Related liver disease name

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Hepatocellular carcinoma

Database cross reference

HGNC:7773
MIM:607379
Ensembl:ENSG00000186575
HPRD:06980
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001707

mesoderm formation

GO:0001953

negative regulation of cell-matrix adhesion

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005730

nucleolus

GO:0005737

cytoplasm

GO:0005769

early endosome

GO:0005856

cytoskeleton

GO:0005886

plasma membrane

GO:0005912

adherens junction

GO:0006469

negative regulation of protein kinase activity

GO:0007398

ectoderm development

GO:0008092

cytoskeletal protein binding

GO:0008156

negative regulation of DNA replication

GO:0008285

negative regulation of cell proliferation

GO:0014010

Schwann cell proliferation

GO:0019898

extrinsic to membrane

GO:0022408

negative regulation of cell-cell adhesion

GO:0030027

lamellipodium

GO:0030036

actin cytoskeleton organization

GO:0030336

negative regulation of cell migration

GO:0031527

filopodium membrane

GO:0032154

cleavage furrow

GO:0032587

ruffle membrane

GO:0035330

regulation of hippo signaling cascade

GO:0042475

odontogenesis of dentine-containing tooth

GO:0042518

negative regulation of tyrosine phosphorylation of Stat3 protein

GO:0042524

negative regulation of tyrosine phosphorylation of Stat5 protein

GO:0043409

negative regulation of MAPKKK cascade

GO:0045216

cell-cell junction organization

GO:0046426

negative regulation of JAK-STAT cascade

GO:0048471

perinuclear region of cytoplasm

GO:0051496

positive regulation of stress fiber assembly

GO:0070306

lens fiber cell differentiation