HuLG003222

Entrez Gene ID

4843

Official Gene Symbol

NOS2

Synonyms

HEPNNOS|INOS|NOS|NOS2A

Gene name

nitric oxide synthase 2, inducible

Gene Type

protein-coding

Chromosome

17

Genomics Location

17q11.2-q12

Known cancer genes

Yes

Protein products

Nitric oxide synthase, inducible

Related liver disease name

Hepatitis

Liver fibrosis and liver cirrhosis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Drug-induced hepatitis

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:7873
MIM:163730
Ensembl:ENSG00000007171
HPRD:01225
RefSeq Genomic nucleotide accession:AC_000060
RefSeq Genomic nucleotide gi:89161195

GO annotation

GO:0001666

response to hypoxia

GO:0001912

positive regulation of leukocyte mediated cytotoxicity

GO:0002227

innate immune response in mucosa

GO:0004517

nitric-oxide synthase activity

GO:0005515

protein binding

GO:0005516

calmodulin binding

GO:0005622

intracellular

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005829

cytosol

GO:0006527

arginine catabolic process

GO:0006801

superoxide metabolic process

GO:0006809

nitric oxide biosynthetic process

GO:0007596

blood coagulation

GO:0010181

FMN binding

GO:0016491

oxidoreductase activity

GO:0018119

peptidyl-cysteine S-nitrosylation

GO:0020037

heme binding

GO:0030168

platelet activation

GO:0030863

cortical cytoskeleton

GO:0034617

tetrahydrobiopterin binding

GO:0034618

arginine binding

GO:0042127

regulation of cell proliferation

GO:0042742

defense response to bacterium

GO:0042803

protein homodimerization activity

GO:0043457

regulation of cellular respiration

GO:0046872

metal ion binding

GO:0048471

perinuclear region of cytoplasm

GO:0050660

flavin adenine dinucleotide binding

GO:0050661

NADP binding

GO:0050796

regulation of insulin secretion

GO:0050829

defense response to Gram-negative bacterium

GO:0051712

positive regulation of killing of cells of other organism