Gene basic information
| LiverAtlas Gene ID |
HuLG003223 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
NOS3 |
|
Synonyms |
ECNOS|eNOS |
|
Gene name |
nitric oxide synthase 3 (endothelial cell) |
|
Gene Type |
protein-coding |
|
Chromosome |
7 |
|
Genomics Location |
7q36 |
|
Known cancer genes |
Yes |
|
Protein products |
Endothelial nitric oxide synthase splice variant eNOS13A Endothelial nitric oxide synthase splice variant eNOS13B |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:7876
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000139 |
Golgi membrane |
|
GO:0001542 |
ovulation from ovarian follicle |
|
GO:0001666 |
response to hypoxia |
|
GO:0001701 |
in utero embryonic development |
|
GO:0001974 |
blood vessel remodeling |
|
GO:0002028 |
regulation of sodium ion transport |
|
GO:0003100 |
regulation of systemic arterial blood pressure by endothelin |
|
GO:0003785 |
actin monomer binding |
|
GO:0004517 |
nitric-oxide synthase activity |
|
GO:0005515 |
protein binding |
|
GO:0005516 |
calmodulin binding |
|
GO:0005625 |
soluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005730 |
nucleolus |
|
GO:0005737 |
cytoplasm |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005829 |
cytosol |
|
GO:0005856 |
cytoskeleton |
|
GO:0005886 |
plasma membrane |
|
GO:0005901 |
caveola |
|
GO:0006527 |
arginine catabolic process |
|
GO:0006809 |
nitric oxide biosynthetic process |
|
GO:0006916 |
anti-apoptosis |
|
GO:0007005 |
mitochondrion organization |
|
GO:0007165 |
signal transduction |
|
GO:0007568 |
aging |
|
GO:0007596 |
blood coagulation |
|
GO:0008217 |
regulation of blood pressure |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0009408 |
response to heat |
|
GO:0010181 |
FMN binding |
|
GO:0010288 |
response to lead ion |
|
GO:0010544 |
negative regulation of platelet activation |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0014740 |
negative regulation of muscle hyperplasia |
|
GO:0014806 |
smooth muscle hyperplasia |
|
GO:0016491 |
oxidoreductase activity |
|
GO:0020037 |
heme binding |
|
GO:0030168 |
platelet activation |
|
GO:0030324 |
lung development |
|
GO:0031284 |
positive regulation of guanylate cyclase activity |
|
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
|
GO:0032355 |
response to estradiol stimulus |
|
GO:0032496 |
response to lipopolysaccharide |
|
GO:0034097 |
response to cytokine stimulus |
|
GO:0034405 |
response to fluid shear stress |
|
GO:0034617 |
tetrahydrobiopterin binding |
|
GO:0034618 |
arginine binding |
|
GO:0042493 |
response to drug |
|
GO:0043200 |
response to amino acid stimulus |
|
GO:0043267 |
negative regulation of potassium ion transport |
|
GO:0043434 |
response to peptide hormone stimulus |
|
GO:0043542 |
endothelial cell migration |
|
GO:0045177 |
apical part of cell |
|
GO:0045471 |
response to ethanol |
|
GO:0045766 |
positive regulation of angiogenesis |
|
GO:0045909 |
positive regulation of vasodilation |
|
GO:0046209 |
nitric oxide metabolic process |
|
GO:0046870 |
cadmium ion binding |
|
GO:0046872 |
metal ion binding |
|
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
|
GO:0050660 |
flavin adenine dinucleotide binding |
|
GO:0050661 |
NADP binding |
|
GO:0050880 |
regulation of blood vessel size |
|
GO:0050999 |
regulation of nitric-oxide synthase activity |
|
GO:0051346 |
negative regulation of hydrolase activity |
|
GO:0051926 |
negative regulation of calcium ion transport |
|
GO:0055093 |
response to hyperoxia |
|
GO:0055094 |
response to lipoprotein stimulus |
