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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG003231

Entrez Gene ID

4855

Official Gene Symbol

NOTCH4

Synonyms

FLJ16302|INT3|MGC74442|NOTCH3

Gene name

notch 4

Gene Type

protein-coding

Chromosome

6

Genomics Location

6p21.3

Known cancer genes

Yes

Protein products

NOTCH4 protein

Neurogenic locus notch homolog protein 4

Notch homolog 4 (Drosophila)

Notch homolog 4 (Drosophila)

NOTCH4 protein

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D

Hepatitis E

Hepatocellular carcinoma

Database cross reference

HGNC:7884
MIM:164951
Ensembl:ENSG00000204301
HPRD:01290
RefSeq Genomic nucleotide accession:AC_000049
RefSeq Genomic nucleotide gi:89161209

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0001569

patterning of blood vessels

GO:0001709

cell fate determination

GO:0001763

morphogenesis of a branching structure

GO:0001886

endothelial cell morphogenesis

GO:0004872

receptor activity

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005634

nucleus

GO:0005654

nucleoplasm

GO:0005788

endoplasmic reticulum lumen

GO:0005796

Golgi lumen

GO:0005829

cytosol

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0007219

Notch signaling pathway

GO:0007220

Notch receptor processing

GO:0009790

embryo development

GO:0009986

cell surface

GO:0010467

gene expression

GO:0030097

hemopoiesis

GO:0030154

cell differentiation

GO:0030879

mammary gland development

GO:0045596

negative regulation of cell differentiation

GO:0045602

negative regulation of endothelial cell differentiation

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0046982

protein heterodimerization activity

GO:0050793

regulation of developmental process