Gene basic information
| LiverAtlas Gene ID |
HuLG003355 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
FURIN |
|
Synonyms |
FUR|PACE|PCSK3|SPC1 |
|
Gene name |
furin (paired basic amino acid cleaving enzyme) |
|
Gene Type |
protein-coding |
|
Chromosome |
15 |
|
Genomics Location |
15q26.1 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
Liver fibrosis and liver cirrhosis Liver fibrosis and liver cirrhosis caused by hepatitis B infection |
|
Database cross reference |
HGNC:8568
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000139 |
Golgi membrane |
|
GO:0002020 |
protease binding |
|
GO:0004175 |
endopeptidase activity |
|
GO:0004252 |
serine-type endopeptidase activity |
|
GO:0004867 |
serine-type endopeptidase inhibitor activity |
|
GO:0005515 |
protein binding |
|
GO:0005615 |
extracellular space |
|
GO:0005789 |
endoplasmic reticulum membrane |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005796 |
Golgi lumen |
|
GO:0005802 |
trans-Golgi network |
|
GO:0005886 |
plasma membrane |
|
GO:0006465 |
signal peptide processing |
|
GO:0006508 |
proteolysis |
|
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
|
GO:0007219 |
Notch signaling pathway |
|
GO:0007568 |
aging |
|
GO:0008233 |
peptidase activity |
|
GO:0008283 |
cell proliferation |
|
GO:0009986 |
cell surface |
|
GO:0016021 |
integral to membrane |
|
GO:0016486 |
peptide hormone processing |
|
GO:0017187 |
peptidyl-glutamic acid carboxylation |
|
GO:0019067 |
viral assembly, maturation, egress, and release |
|
GO:0030140 |
trans-Golgi network transport vesicle |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
|
GO:0031985 |
Golgi cisterna |
|
GO:0032455 |
nerve growth factor processing |
|
GO:0032804 |
negative regulation of low-density lipoprotein particle receptor catabolic process |
|
GO:0032902 |
nerve growth factor production |
|
GO:0032904 |
negative regulation of nerve growth factor production |
|
GO:0032911 |
negative regulation of transforming growth factor-beta1 production |
|
GO:0032940 |
secretion by cell |
|
GO:0042176 |
regulation of protein catabolic process |
|
GO:0042277 |
peptide binding |
|
GO:0043043 |
peptide biosynthetic process |
|
GO:0043687 |
post-translational protein modification |
|
GO:0044267 |
cellular protein metabolic process |
|
GO:0045121 |
membrane raft |
|
GO:0046872 |
metal ion binding |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048406 |
nerve growth factor binding |
|
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
|
GO:0051605 |
protein maturation by peptide bond cleavage |
|
GO:0052548 |
regulation of endopeptidase activity |
