HuLG003437

Entrez Gene ID

5155

Official Gene Symbol

PDGFB

Synonyms

FLJ12858|PDGF2|SIS|SSV|cNsis

Gene name

platelet-derived growth factor beta polypeptide

Gene Type

protein-coding

Chromosome

22

Genomics Location

22q12.3-q13.1|22q13.1

Known cancer genes

Yes

Protein products

Platelet-derived growth factor 2

Platelet-derived growth factor subunit B

Orf 2 protein

Related liver disease name

Liver fibrosis and liver cirrhosis

Chronic hepatitis

Hepatocellular carcinoma

Database cross reference

HGNC:8800
MIM:190040
Ensembl:ENSG00000100311
HPRD:01815
RefSeq Genomic nucleotide accession:AC_000065
RefSeq Genomic nucleotide gi:89161202

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

GO annotation

GO:0000139

Golgi membrane

GO:0001666

response to hypoxia

GO:0001892

embryonic placenta development

GO:0001938

positive regulation of endothelial cell proliferation

GO:0002548

monocyte chemotaxis

GO:0002576

platelet degranulation

GO:0003104

positive regulation of glomerular filtration

GO:0005161

platelet-derived growth factor receptor binding

GO:0005515

protein binding

GO:0005518

collagen binding

GO:0005576

extracellular region

GO:0005737

cytoplasm

GO:0005788

endoplasmic reticulum lumen

GO:0006468

protein phosphorylation

GO:0006929

substrate-dependent cell migration

GO:0007179

transforming growth factor beta receptor signaling pathway

GO:0007507

heart development

GO:0007596

blood coagulation

GO:0008083

growth factor activity

GO:0008284

positive regulation of cell proliferation

GO:0009611

response to wounding

GO:0009986

cell surface

GO:0010512

negative regulation of phosphatidylinositol biosynthetic process

GO:0010544

negative regulation of platelet activation

GO:0014068

positive regulation of phosphatidylinositol 3-kinase cascade

GO:0014070

response to organic cyclic compound

GO:0014911

positive regulation of smooth muscle cell migration

GO:0016020

membrane

GO:0016049

cell growth

GO:0016176

superoxide-generating NADPH oxidase activator activity

GO:0016323

basolateral plasma membrane

GO:0018105

peptidyl-serine phosphorylation

GO:0018108

peptidyl-tyrosine phosphorylation

GO:0030031

cell projection assembly

GO:0030036

actin cytoskeleton organization

GO:0030097

hemopoiesis

GO:0030168

platelet activation

GO:0030335

positive regulation of cell migration

GO:0030336

negative regulation of cell migration

GO:0031093

platelet alpha granule lumen

GO:0031954

positive regulation of protein autophosphorylation

GO:0032147

activation of protein kinase activity

GO:0032148

activation of protein kinase B activity

GO:0032355

response to estradiol stimulus

GO:0032868

response to insulin stimulus

GO:0035793

positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

GO:0038001

paracrine signaling

GO:0042493

response to drug

GO:0042802

identical protein binding

GO:0042803

protein homodimerization activity

GO:0043406

positive regulation of MAP kinase activity

GO:0043410

positive regulation of MAPKKK cascade

GO:0043498

cell surface binding

GO:0043499

eukaryotic cell surface binding

GO:0043536

positive regulation of blood vessel endothelial cell migration

GO:0043552

positive regulation of phosphatidylinositol 3-kinase activity

GO:0045737

positive regulation of cyclin-dependent protein kinase activity

GO:0045740

positive regulation of DNA replication

GO:0045743

positive regulation of fibroblast growth factor receptor signaling pathway

GO:0045840

positive regulation of mitosis

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0046982

protein heterodimerization activity

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO:0048146

positive regulation of fibroblast proliferation

GO:0048407

platelet-derived growth factor binding

GO:0048661

positive regulation of smooth muscle cell proliferation

GO:0050730

regulation of peptidyl-tyrosine phosphorylation

GO:0050921

positive regulation of chemotaxis

GO:0051781

positive regulation of cell division

GO:0060326

cell chemotaxis

GO:0060445

branching involved in salivary gland morphogenesis

GO:0060664

epithelial cell proliferation involved in salivary gland morphogenesis

GO:0061098

positive regulation of protein tyrosine kinase activity

GO:0070374

positive regulation of ERK1 and ERK2 cascade

GO:0071506

cellular response to mycophenolic acid

GO:0072126

positive regulation of glomerular mesangial cell proliferation

GO:0072255

metanephric glomerular mesangial cell development

GO:0072593

reactive oxygen species metabolic process

GO:0090280

positive regulation of calcium ion import

GO:2000379

positive regulation of reactive oxygen species metabolic process

GO:2000573

positive regulation of DNA biosynthetic process

GO:2000591

positive regulation of metanephric mesenchymal cell migration