HuLG003503

Entrez Gene ID

5244

Official Gene Symbol

ABCB4

Synonyms

ABC21|GBD1|MDR2|MDR2/3|MDR3|PFICN3|PGY3

Gene name

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Gene Type

protein-coding

Chromosome

7

Genomics Location

7q21.1

Known cancer genes

Yes

Protein products

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Variant ATP-binding cassette sub-family B member 4

Uncharacterized protein

Multidrug resistance protein 3

Multidrug resistance protein 3

ATP-binding cassette, sub-family B (MDR/TAP), member 4

ABCB4 protein

Putative uncharacterized protein ABCB4

Related liver disease name

Liver fibrosis and liver cirrhosis

Hepatitis C

Chronic hepatitis C

Biliary cirrhosis

Hepatocellular carcinoma

Primary biliary cirrhosis

Primary sclerosing cholangitis

Database cross reference

HGNC:45
MIM:171060
Ensembl:ENSG00000005471
HPRD:01371
RefSeq Genomic nucleotide accession:AC_000050
RefSeq Genomic nucleotide gi:89161211

HCC significant genes

Yes/No

Yes

Evidence

EHCO HCC.net

Quality score

GO annotation

GO:0000139

Golgi membrane

GO:0000166

nucleotide binding

GO:0005524

ATP binding

GO:0005624

membrane fraction

GO:0005886

plasma membrane

GO:0005887

integral to plasma membrane

GO:0006629

lipid metabolic process

GO:0006810

transport

GO:0008559

xenobiotic-transporting ATPase activity

GO:0016021

integral to membrane

GO:0016324

apical plasma membrane

GO:0016787

hydrolase activity

GO:0016887

ATPase activity

GO:0042493

response to drug

GO:0042626

ATPase activity, coupled to transmembrane movement of substances

GO:0044255

cellular lipid metabolic process

GO:0046581

intercellular canaliculus

GO:0051384

response to glucocorticoid stimulus

GO:0055085

transmembrane transport