Gene basic information
| LiverAtlas Gene ID |
HuLG003588 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PLK1 |
|
Synonyms |
PLK|STPK13 |
|
Gene name |
polo-like kinase 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
16 |
|
Genomics Location |
16p12.2 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:9077
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000086 |
G2/M transition of mitotic cell cycle |
|
GO:0000087 |
M phase of mitotic cell cycle |
|
GO:0000088 |
mitotic prophase |
|
GO:0000166 |
nucleotide binding |
|
GO:0000236 |
mitotic prometaphase |
|
GO:0000278 |
mitotic cell cycle |
|
GO:0000776 |
kinetochore |
|
GO:0000777 |
condensed chromosome kinetochore |
|
GO:0000910 |
cytokinesis |
|
GO:0000922 |
spindle pole |
|
GO:0000942 |
condensed nuclear chromosome outer kinetochore |
|
GO:0004672 |
protein kinase activity |
|
GO:0004674 |
protein serine/threonine kinase activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005634 |
nucleus |
|
GO:0005654 |
nucleoplasm |
|
GO:0005694 |
chromosome |
|
GO:0005737 |
cytoplasm |
|
GO:0005813 |
centrosome |
|
GO:0005829 |
cytosol |
|
GO:0005856 |
cytoskeleton |
|
GO:0005876 |
spindle microtubule |
|
GO:0007067 |
mitosis |
|
GO:0007091 |
mitotic metaphase/anaphase transition |
|
GO:0007346 |
regulation of mitotic cell cycle |
|
GO:0008283 |
cell proliferation |
|
GO:0010800 |
positive regulation of peptidyl-threonine phosphorylation |
|
GO:0010997 |
anaphase-promoting complex binding |
|
GO:0016301 |
kinase activity |
|
GO:0016310 |
phosphorylation |
|
GO:0016567 |
protein ubiquitination |
|
GO:0018105 |
peptidyl-serine phosphorylation |
|
GO:0019901 |
protein kinase binding |
|
GO:0031145 |
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process |
|
GO:0031572 |
G2/M transition DNA damage checkpoint |
|
GO:0031648 |
protein destabilization |
|
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
|
GO:0040038 |
polar body extrusion after meiotic divisions |
|
GO:0042801 |
polo kinase kinase activity |
|
GO:0043393 |
regulation of protein binding |
|
GO:0045736 |
negative regulation of cyclin-dependent protein kinase activity |
|
GO:0045862 |
positive regulation of proteolysis |
|
GO:0046677 |
response to antibiotic |
|
GO:0051233 |
spindle midzone |
|
GO:0051437 |
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
|
GO:0051439 |
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
|
GO:0051443 |
positive regulation of ubiquitin-protein ligase activity |
|
GO:0051726 |
regulation of cell cycle |
|
GO:0071168 |
protein localization to chromatin |
|
GO:0090007 |
regulation of mitotic anaphase |
