Gene basic information
| LiverAtlas Gene ID |
HuLG003700 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PPP2CA |
|
Synonyms |
PP2Ac|PP2CA|PP2Calpha|RPNC |
|
Gene name |
protein phosphatase 2, catalytic subunit, alpha isozyme |
|
Gene Type |
protein-coding |
|
Chromosome |
5 |
|
Genomics Location |
5q31.1 |
|
Known cancer genes |
Yes |
|
Protein products |
Serine/threonine-protein phosphatase Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:9299
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000159 |
protein phosphatase type 2A complex |
|
GO:0000188 |
inactivation of MAPK activity |
|
GO:0000775 |
chromosome, centromeric region |
|
GO:0000922 |
spindle pole |
|
GO:0004721 |
phosphoprotein phosphatase activity |
|
GO:0005515 |
protein binding |
|
GO:0005625 |
soluble fraction |
|
GO:0005634 |
nucleus |
|
GO:0005694 |
chromosome |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005829 |
cytosol |
|
GO:0005886 |
plasma membrane |
|
GO:0006275 |
regulation of DNA replication |
|
GO:0006355 |
regulation of transcription, DNA-dependent |
|
GO:0006470 |
protein dephosphorylation |
|
GO:0006672 |
ceramide metabolic process |
|
GO:0006917 |
induction of apoptosis |
|
GO:0007126 |
meiosis |
|
GO:0007498 |
mesoderm development |
|
GO:0008022 |
protein C-terminus binding |
|
GO:0008380 |
RNA splicing |
|
GO:0010033 |
response to organic substance |
|
GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
|
GO:0015630 |
microtubule cytoskeleton |
|
GO:0016020 |
membrane |
|
GO:0016787 |
hydrolase activity |
|
GO:0019932 |
second-messenger-mediated signaling |
|
GO:0030111 |
regulation of Wnt receptor signaling pathway |
|
GO:0030155 |
regulation of cell adhesion |
|
GO:0030308 |
negative regulation of cell growth |
|
GO:0040008 |
regulation of growth |
|
GO:0042518 |
negative regulation of tyrosine phosphorylation of Stat3 protein |
|
GO:0045595 |
regulation of cell differentiation |
|
GO:0046872 |
metal ion binding |
|
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
