Gene basic information
| LiverAtlas Gene ID |
HuLG003777 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
MAP2K1 |
|
Synonyms |
MAPKK1|MEK1|MKK1|PRKMK1 |
|
Gene name |
mitogen-activated protein kinase kinase 1 |
|
Gene Type |
protein-coding |
|
Chromosome |
15 |
|
Genomics Location |
15q22.1-q22.33 |
|
Known cancer genes |
Yes |
|
Protein products |
Mitogen-activated protein kinase kinase 1 |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:6840
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net OncoDB |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000165 |
MAPKKK cascade |
|
GO:0000166 |
nucleotide binding |
|
GO:0000186 |
activation of MAPKK activity |
|
GO:0000187 |
activation of MAPK activity |
|
GO:0002224 |
toll-like receptor signaling pathway |
|
GO:0002755 |
MyD88-dependent toll-like receptor signaling pathway |
|
GO:0002756 |
MyD88-independent toll-like receptor signaling pathway |
|
GO:0003056 |
regulation of vascular smooth muscle contraction |
|
GO:0004672 |
protein kinase activity |
|
GO:0004674 |
protein serine/threonine kinase activity |
|
GO:0004708 |
MAP kinase kinase activity |
|
GO:0004713 |
protein tyrosine kinase activity |
|
GO:0004728 |
receptor signaling protein tyrosine phosphatase activity |
|
GO:0005515 |
protein binding |
|
GO:0005524 |
ATP binding |
|
GO:0005625 |
soluble fraction |
|
GO:0005737 |
cytoplasm |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005829 |
cytosol |
|
GO:0005874 |
microtubule |
|
GO:0005886 |
plasma membrane |
|
GO:0005938 |
cell cortex |
|
GO:0006928 |
cellular component movement |
|
GO:0006935 |
chemotaxis |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007050 |
cell cycle arrest |
|
GO:0007067 |
mitosis |
|
GO:0007165 |
signal transduction |
|
GO:0007173 |
epidermal growth factor receptor signaling pathway |
|
GO:0007264 |
small GTPase mediated signal transduction |
|
GO:0007265 |
Ras protein signal transduction |
|
GO:0007411 |
axon guidance |
|
GO:0008063 |
Toll signaling pathway |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008286 |
insulin receptor signaling pathway |
|
GO:0017016 |
Ras GTPase binding |
|
GO:0030182 |
neuron differentiation |
|
GO:0030216 |
keratinocyte differentiation |
|
GO:0030335 |
positive regulation of cell migration |
|
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
|
GO:0032320 |
positive regulation of Ras GTPase activity |
|
GO:0032402 |
melanosome transport |
|
GO:0032839 |
dendrite cytoplasm |
|
GO:0032968 |
positive regulation of transcription elongation from RNA polymerase II promoter |
|
GO:0033267 |
axon part |
|
GO:0034111 |
negative regulation of homotypic cell-cell adhesion |
|
GO:0034130 |
toll-like receptor 1 signaling pathway |
|
GO:0034134 |
toll-like receptor 2 signaling pathway |
|
GO:0034138 |
toll-like receptor 3 signaling pathway |
|
GO:0034142 |
toll-like receptor 4 signaling pathway |
|
GO:0043204 |
perikaryon |
|
GO:0045087 |
innate immune response |
|
GO:0045597 |
positive regulation of cell differentiation |
|
GO:0047496 |
vesicle transport along microtubule |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048313 |
Golgi inheritance |
|
GO:0048471 |
perinuclear region of cytoplasm |
|
GO:0048678 |
response to axon injury |
|
GO:0048812 |
neuron projection morphogenesis |
|
GO:0048870 |
cell motility |
|
GO:0051291 |
protein heterooligomerization |
|
GO:0051384 |
response to glucocorticoid stimulus |
|
GO:0051403 |
stress-activated MAPK cascade |
|
GO:0060674 |
placenta blood vessel development |
|
GO:0060711 |
labyrinthine layer development |
|
GO:0090398 |
cellular senescence |
