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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG003793

Entrez Gene ID

5624

Official Gene Symbol

PROC

Synonyms

APC|PC|PROC1

Gene name

protein C (inactivator of coagulation factors Va and VIIIa)

Gene Type

protein-coding

Chromosome

2

Genomics Location

2q13-q14

Known cancer genes

Yes

Protein products

Vitamin K-dependent protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Protein C

Related liver disease name

Hepatocellular carcinoma

Nonalcoholic steatohepatitis

Primary sclerosing cholangitis

Database cross reference

HGNC:9451
MIM:612283
Ensembl:ENSG00000115718
HPRD:01466
RefSeq Genomic nucleotide accession:AC_000045
RefSeq Genomic nucleotide gi:89161198

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0004252

serine-type endopeptidase activity

GO:0005509

calcium ion binding

GO:0005515

protein binding

GO:0005576

extracellular region

GO:0005615

extracellular space

GO:0005788

endoplasmic reticulum lumen

GO:0005796

Golgi lumen

GO:0005886

plasma membrane

GO:0006508

proteolysis

GO:0007596

blood coagulation

GO:0008233

peptidase activity

GO:0017187

peptidyl-glutamic acid carboxylation

GO:0030195

negative regulation of blood coagulation

GO:0043066

negative regulation of apoptosis

GO:0043687

post-translational protein modification

GO:0044267

cellular protein metabolic process

GO:0050900

leukocyte migration