HuLG003797

Entrez Gene ID

5629

Official Gene Symbol

PROX1

Gene name

prospero homeobox 1

Gene Type

protein-coding

Chromosome

1

Genomics Location

1q41

Known cancer genes

Yes

Protein products

Prospero homeobox protein 1

Related liver disease name

Hepatocellular carcinoma

Intrahepatic cholangiocarcinoma

Database cross reference

HGNC:9459
MIM:601546
Ensembl:ENSG00000117707
HPRD:03330
RefSeq Genomic nucleotide accession:AC_000044
RefSeq Genomic nucleotide gi:89161184

HCC significant genes

Yes/No

Yes

Evidence

HCC.net

Quality score

GO annotation

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

GO:0001709

cell fate determination

GO:0001822

kidney development

GO:0001889

liver development

GO:0001938

positive regulation of endothelial cell proliferation

GO:0001946

lymphangiogenesis

GO:0002088

lens development in camera-type eye

GO:0003677

DNA binding

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

GO:0003714

transcription corepressor activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0007275

multicellular organismal development

GO:0007420

brain development

GO:0008284

positive regulation of cell proliferation

GO:0008285

negative regulation of cell proliferation

GO:0010468

regulation of gene expression

GO:0010595

positive regulation of endothelial cell migration

GO:0016922

ligand-dependent nuclear receptor binding

GO:0021516

dorsal spinal cord development

GO:0021915

neural tube development

GO:0030240

skeletal muscle thin filament assembly

GO:0030324

lung development

GO:0030910

olfactory placode formation

GO:0031016

pancreas development

GO:0043049

otic placode formation

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

GO:0045071

negative regulation of viral genome replication

GO:0045737

positive regulation of cyclin-dependent protein kinase activity

GO:0045750

positive regulation of S phase of mitotic cell cycle

GO:0045787

positive regulation of cell cycle

GO:0045892

negative regulation of transcription, DNA-dependent

GO:0045893

positive regulation of transcription, DNA-dependent

GO:0046619

optic placode formation involved in camera-type eye formation

GO:0048845

venous blood vessel morphogenesis

GO:0050692

DBD domain binding

GO:0050693

LBD domain binding

GO:0055005

ventricular cardiac myofibril development

GO:0055009

atrial cardiac muscle tissue morphogenesis

GO:0055010

ventricular cardiac muscle tissue morphogenesis

GO:0060042

retina morphogenesis in camera-type eye

GO:0060059

embryonic retina morphogenesis in camera-type eye

GO:0060214

endocardium formation

GO:0060298

positive regulation of sarcomere organization

GO:0060412

ventricular septum morphogenesis

GO:0060414

aorta smooth muscle tissue morphogenesis

GO:0060421

positive regulation of heart growth

GO:0060836

lymphatic endothelial cell differentiation

GO:0060849

regulation of transcription involved in lymphatic endothelial cell fate commitment

GO:0070309

lens fiber cell morphogenesis

GO:0070365

hepatocyte differentiation

GO:0070858

negative regulation of bile acid biosynthetic process