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Gene, Transcriptome, Protein, Pathway or Disease. 

Gene basic information

LiverAtlas Gene ID

HuLG003846

Entrez Gene ID

5696

Official Gene Symbol

PSMB8

Synonyms

D6S216|D6S216E|LMP7|MGC1491|PSMB5i|RING10

Gene name

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)

Gene Type

protein-coding

Chromosome

6

Genomics Location

6p21.3

Protein products

Proteasome subunit beta type-8

PSMB8 protein

Related liver disease name

Hepatitis

Viral hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Chronic hepatitis C

Hepatitis D

Hepatitis E

Chronic hepatitis

Hepatocellular carcinoma

Database cross reference

HGNC:9545
MIM:177046
Ensembl:ENSG00000204264
HPRD:01515
RefSeq Genomic nucleotide accession:AC_000049
RefSeq Genomic nucleotide gi:89161209

Liver relevance

HCC significant genes

Yes/No

Yes

Evidence

EHCO

Quality score

 

Ontology annotation

GO ID

GO annotation

GO:0000075

cell cycle checkpoint

GO:0000082

G1/S transition of mitotic cell cycle

GO:0000084

S phase of mitotic cell cycle

GO:0000216

M/G1 transition of mitotic cell cycle

GO:0000278

mitotic cell cycle

GO:0000502

proteasome complex

GO:0004298

threonine-type endopeptidase activity

GO:0005515

protein binding

GO:0005634

nucleus

GO:0005737

cytoplasm

GO:0005839

proteasome core complex

GO:0006521

regulation of cellular amino acid metabolic process

GO:0006915

apoptosis

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

GO:0008233

peptidase activity

GO:0016032

viral reproduction

GO:0016070

RNA metabolic process

GO:0016071

mRNA metabolic process

GO:0019221

cytokine-mediated signaling pathway

GO:0031145

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

GO:0034641

cellular nitrogen compound metabolic process

GO:0042981

regulation of apoptosis

GO:0044419

interspecies interaction between organisms

GO:0051436

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

GO:0051437

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

GO:0051439

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

GO:0051603

proteolysis involved in cellular protein catabolic process

GO:0060337

type I interferon-mediated signaling pathway