Gene basic information
| LiverAtlas Gene ID |
HuLG003875 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PTEN |
|
Synonyms |
10q23del|BZS|DEC|GLM2|MGC11227|MHAM|MMAC1|PTEN1|TEP1 |
|
Gene name |
phosphatase and tensin homolog |
|
Gene Type |
protein-coding |
|
Chromosome |
10 |
|
Genomics Location |
10q23.3 |
|
Known cancer genes |
Yes |
|
Protein products |
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
|
Related liver disease name |
|
|
Database cross reference |
HGNC:9588
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
EHCO HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0000079 |
regulation of cyclin-dependent protein kinase activity |
|
GO:0000287 |
magnesium ion binding |
|
GO:0001525 |
angiogenesis |
|
GO:0001933 |
negative regulation of protein phosphorylation |
|
GO:0002902 |
regulation of B cell apoptosis |
|
GO:0004438 |
phosphatidylinositol-3-phosphatase activity |
|
GO:0004721 |
phosphoprotein phosphatase activity |
|
GO:0004722 |
protein serine/threonine phosphatase activity |
|
GO:0004725 |
protein tyrosine phosphatase activity |
|
GO:0005161 |
platelet-derived growth factor receptor binding |
|
GO:0005515 |
protein binding |
|
GO:0005634 |
nucleus |
|
GO:0005737 |
cytoplasm |
|
GO:0005739 |
mitochondrion |
|
GO:0005829 |
cytosol |
|
GO:0006470 |
protein dephosphorylation |
|
GO:0006629 |
lipid metabolic process |
|
GO:0006917 |
induction of apoptosis |
|
GO:0007092 |
activation of mitotic anaphase-promoting complex activity |
|
GO:0007417 |
central nervous system development |
|
GO:0007507 |
heart development |
|
GO:0007568 |
aging |
|
GO:0007584 |
response to nutrient |
|
GO:0007613 |
memory |
|
GO:0008138 |
protein tyrosine/serine/threonine phosphatase activity |
|
GO:0008283 |
cell proliferation |
|
GO:0008285 |
negative regulation of cell proliferation |
|
GO:0008289 |
lipid binding |
|
GO:0009749 |
response to glucose stimulus |
|
GO:0009898 |
internal side of plasma membrane |
|
GO:0010043 |
response to zinc ion |
|
GO:0010975 |
regulation of neuron projection development |
|
GO:0010997 |
anaphase-promoting complex binding |
|
GO:0014070 |
response to organic cyclic compound |
|
GO:0016314 |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity |
|
GO:0016477 |
cell migration |
|
GO:0016605 |
PML body |
|
GO:0016787 |
hydrolase activity |
|
GO:0019717 |
synaptosome |
|
GO:0019899 |
enzyme binding |
|
GO:0030165 |
PDZ domain binding |
|
GO:0030336 |
negative regulation of cell migration |
|
GO:0031647 |
regulation of protein stability |
|
GO:0031658 |
negative regulation of cyclin-dependent protein kinase activity involved in G1/S |
|
GO:0032355 |
response to estradiol stimulus |
|
GO:0033032 |
regulation of myeloid cell apoptosis |
|
GO:0033198 |
response to ATP |
|
GO:0035335 |
peptidyl-tyrosine dephosphorylation |
|
GO:0042493 |
response to drug |
|
GO:0043066 |
negative regulation of apoptosis |
|
GO:0043197 |
dendritic spine |
|
GO:0043542 |
endothelial cell migration |
|
GO:0045211 |
postsynaptic membrane |
|
GO:0045471 |
response to ethanol |
|
GO:0046685 |
response to arsenic-containing substance |
|
GO:0046855 |
inositol phosphate dephosphorylation |
|
GO:0046856 |
phosphatidylinositol dephosphorylation |
|
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
|
GO:0048011 |
nerve growth factor receptor signaling pathway |
|
GO:0048015 |
phosphatidylinositol-mediated signaling |
|
GO:0048738 |
cardiac muscle tissue development |
|
GO:0050680 |
negative regulation of epithelial cell proliferation |
|
GO:0050765 |
negative regulation of phagocytosis |
|
GO:0050821 |
protein stabilization |
|
GO:0050852 |
T cell receptor signaling pathway |
|
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
|
GO:0051717 |
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
|
GO:0051800 |
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity |
|
GO:0051895 |
negative regulation of focal adhesion assembly |
|
GO:0051898 |
negative regulation of protein kinase B signaling cascade |
|
GO:0060070 |
canonical Wnt receptor signaling pathway |
|
GO:0060292 |
long term synaptic depression |
|
GO:0060736 |
prostate gland growth |
|
GO:2000060 |
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
|
GO:2000134 |
negative regulation of G1/S transition of mitotic cell cycle |
