Gene basic information
| LiverAtlas Gene ID |
HuLG003887 |
|
Entrez Gene ID |
|
|
Official Gene Symbol |
PTGS1 |
|
Synonyms |
COX1|COX3|PCOX1|PGG/HS|PGHSN1|PGHS1|PHS1|PTGHS |
|
Gene name |
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
|
Gene Type |
protein-coding |
|
Chromosome |
9 |
|
Genomics Location |
9q32-q33.3 |
|
Known cancer genes |
Yes |
|
Protein products |
|
|
Related liver disease name |
|
|
Database cross reference |
HGNC:9604
|
Liver relevance
|
HCC significant genes |
Yes/No |
Yes |
|
Evidence |
HCC.net |
|
|
Quality score |
|
Ontology annotation
| GO ID |
GO annotation |
|
GO:0001516 |
prostaglandin biosynthetic process |
|
GO:0001750 |
photoreceptor outer segment |
|
GO:0004601 |
peroxidase activity |
|
GO:0004666 |
prostaglandin-endoperoxide synthase activity |
|
GO:0005634 |
nucleus |
|
GO:0005635 |
nuclear envelope |
|
GO:0005737 |
cytoplasm |
|
GO:0005783 |
endoplasmic reticulum |
|
GO:0005789 |
endoplasmic reticulum membrane |
|
GO:0005792 |
microsome |
|
GO:0005794 |
Golgi apparatus |
|
GO:0005886 |
plasma membrane |
|
GO:0006629 |
lipid metabolic process |
|
GO:0006633 |
fatty acid biosynthetic process |
|
GO:0006692 |
prostanoid metabolic process |
|
GO:0006805 |
xenobiotic metabolic process |
|
GO:0006979 |
response to oxidative stress |
|
GO:0007568 |
aging |
|
GO:0008217 |
regulation of blood pressure |
|
GO:0008289 |
lipid binding |
|
GO:0010243 |
response to organic nitrogen |
|
GO:0010700 |
negative regulation of norepinephrine secretion |
|
GO:0016491 |
oxidoreductase activity |
|
GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
|
GO:0019371 |
cyclooxygenase pathway |
|
GO:0020037 |
heme binding |
|
GO:0032811 |
negative regulation of epinephrine secretion |
|
GO:0042127 |
regulation of cell proliferation |
|
GO:0042446 |
hormone biosynthetic process |
|
GO:0043231 |
intracellular membrane-bounded organelle |
|
GO:0044444 |
cytoplasmic part |
|
GO:0045907 |
positive regulation of vasoconstriction |
|
GO:0045987 |
positive regulation of smooth muscle contraction |
|
GO:0046872 |
metal ion binding |
|
GO:0051412 |
response to corticosterone stimulus |
